|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >
Ablation of microglia does not alter circadian rhythm of locomotor activity
| Title: | Ablation of microglia does not alter circadian rhythm of locomotor activity |
| Authors: | Matsui, Futaba Browse this author | | Yamaguchi, Sho T. T. Browse this author | | Kobayashi, Riho Browse this author | | Ito, Shiho Browse this author | | Nagashima, Sakimi Browse this author | | Zhou, Zhiwen Browse this author | | Norimoto, Hiroaki Browse this author |
| Keywords: | Microglia | | Circadian rhythm | | Suprachiasmatic nucleus |
| Issue Date: | 7-Apr-2023 |
| Publisher: | BioMed Central |
| Journal Title: | Molecular brain |
| Volume: | 16 |
| Issue: | 1 |
| Start Page: | 34 |
| Publisher DOI: | 10.1186/s13041-023-01021-1 |
| Abstract: | Microglia, as macrophages in the brain, are responsible for immune responses and synaptic remodeling. Although the function of microglia is regulated by circadian rhythms, it is still unclear whether microglia are involved in the generation and light entrainment of circadian rhythms of behavior. Here, we report that microglial depletion does not alter behavioral circadian rhythms. We depleted similar to 95% of microglia in the mouse brain by PLX3397, a CSF1R inhibitor, and analyzed the effect on the spontaneous behaviors of mice. We found that neither the free-running period under constant darkness nor light entrainment under jet-lag circumstances were influenced by the ablation of microglia. Our results demonstrate that the circadian rhythms of locomotor activity, an important output of the circadian clock in the brain, are likely a phenomenon not produced by microglia. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89316 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
|
