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Hepatocellular Carcinoma Rupture after Introducing Lenvatinib : An Autopsy Case Report
| Title: | Hepatocellular Carcinoma Rupture after Introducing Lenvatinib : An Autopsy Case Report |
| Authors: | Kohya, Risako Browse this author | | Sugiura, Ryo Browse this author | | Yamamoto, Yoshiya Browse this author | | Naruse, Hirohito Browse this author | | Hatanaka, Kazuteru Browse this author | | Kinoshita, Kenji Browse this author | | Abiko, Satoshi Browse this author | | Miyamoto, Shuichi Browse this author | | Suzuki, Kazuharu Browse this author | | Kushibiki, Hanae Browse this author | | Munakata, Satoru Browse this author | | Shimoyama, Norihiko Browse this author |
| Keywords: | adverse effect | | autopsy case | | hepatocellular carcinoma | | lenvatinib |
| Issue Date: | 1-Apr-2023 |
| Publisher: | 日本内科学会(The Japanese Society of Internal Medicine) |
| Journal Title: | Internal medicine |
| Volume: | 62 |
| Issue: | 7 |
| Start Page: | 995 |
| End Page: | 998 |
| Publisher DOI: | 10.2169/internalmedicine.0114-22 |
| Abstract: | Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/89319 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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