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Hepatocellular Carcinoma Rupture after Introducing Lenvatinib : An Autopsy Case Report

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Title: Hepatocellular Carcinoma Rupture after Introducing Lenvatinib : An Autopsy Case Report
Authors: Kohya, Risako Browse this author
Sugiura, Ryo Browse this author
Yamamoto, Yoshiya Browse this author
Naruse, Hirohito Browse this author
Hatanaka, Kazuteru Browse this author
Kinoshita, Kenji Browse this author
Abiko, Satoshi Browse this author
Miyamoto, Shuichi Browse this author
Suzuki, Kazuharu Browse this author
Kushibiki, Hanae Browse this author
Munakata, Satoru Browse this author
Shimoyama, Norihiko Browse this author
Keywords: adverse effect
autopsy case
hepatocellular carcinoma
Issue Date: 1-Apr-2023
Publisher: 日本内科学会(The Japanese Society of Internal Medicine)
Journal Title: Internal medicine
Volume: 62
Issue: 7
Start Page: 995
End Page: 998
Publisher DOI: 10.2169/internalmedicine.0114-22
Abstract: Hepatocellular carcinoma (HCC) hemorrhaging/rupture is a rare adverse effect of lenvatinib, and only limited pathological examinations have been reported. This report presents the case of a 69-year-old man who suffered from cardiac arrest and died 7 days after starting lenvatinib treatment for HCC, with an autopsy subsequently performed. Crack and coagulated blood were observed in the largest tumor. Pathologically, the hemorrhaging area was scattered in nearly all of the HCC lesions, regardless of tumor differentiation. This pathological feature is unusual in normal HCC. Thus, it is believed to have been the effect of lenvatinib.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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