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Suppressive modulation of host immune responses by Dermanyssus gallinae infestation

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Title: Suppressive modulation of host immune responses by Dermanyssus gallinae infestation
Authors: Fujisawa, Sotaro Browse this author
Murata, Shiro Browse this author →KAKEN DB
Isezaki, Masayoshi Browse this author
Win, Shwe Yee Browse this author
Sato, Takumi Browse this author
Oishi, Eiji Browse this author
Taneno, Akira Browse this author
Maekawa, Naoya Browse this author →KAKEN DB
Okagawa, Tomohiro Browse this author →KAKEN DB
Konnai, Satoru Browse this author →KAKEN DB
Ohashi, Kazuhiko Browse this author →KAKEN DB
Keywords: Dermanyssus gallinae
poultry red mite
Issue Date: Apr-2023
Publisher: Elsevier
Journal Title: Poultry Science
Volume: 102
Issue: 4
Start Page: 102532
Publisher DOI: 10.1016/j.psj.2023.102532
Abstract: The poultry red mite (Dermanyssus galli-nae, PRM) is a blood-sucking ectoparasite in chickens and is one of the most serious threats to poultry farms. Mass infestation with PRMs causes various health prob-lems in chickens, resulting in significant productivity reduction in the poultry industry. Infestation with hema-tophagous ectoparasites, such as ticks, induces host inflammatory and hemostatic reactions. On the other hand, several studies have reported that hematophagous ectoparasites secrete various immunosuppressants from their saliva to suppress host immune responses to main-tain blood sucking. Here, we examined the expression of cytokines in peripheral blood cells to investigate whether PRM infestation affects immunological states in chickens. In PRM-infested chickens, anti-inflammatory cytokines, IL-10 and TGF-b1, and immune checkpoint molecules, CTLA-4 and PD-1, were highly expressed compared to noninfested chickens. PRM-derived soluble mite extracts (SME) upregulated the gene expression of IL-10 in peripheral blood cells and HD-11 chicken macrophages. In addition, SME suppressed the expression of interferons and inflammatory cytokines in HD-11 chicken macro-phages. Moreover, SME induces the polarization of mac-rophages into anti-inflammatory phenotypes. Collectively, PRM infestation could affect host immune responses, especially suppress the inflammatory responses. Further studies are warranted to fully understand the influence of PRM infestation on host immunity.
Type: article
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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