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Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats
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| Title: | Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats |
| Other Titles: | ラットにおけるエメチン誘発条件付け味覚忌避に対する最後野破壊および横隔膜下両側迷走神経求心路切除の効果 |
| Authors: | 蘇, 韶懿 Browse this author |
| Keywords: | Emetine | | Nausea | | Area postrema | | Vagal afferent | | CTA |
| Issue Date: | 23-Mar-2023 |
| Publisher: | Hokkaido University |
| Abstract: | We investigated the effect of area postrema lesions and selective vagotomy of afferent fibers on emetine-induced nausea in rats. We evaluated the acquisition of the conditioned taste avoidance (CTA) to 0.1% saccharin solution after conditioning with emetine dihydrochloride (5.54 mg/kg, i.p., 1% BW). The CTA was measured in three groups of rats: a bilateral subdiaphragmatic afferent vagotomy group, an area postrema lesion group, and a sham lesion group. The bilateral vagotomy and sham groups of rats showed acquisition of CTA within 2 days of the test date. Taste avoidance was never conditioned in the area postrema lesion group. These results indicate that the area postrema plays a crucial role in the induction of emetine-induced nausea. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第15483号 |
| Degree Level: | 博士 |
| Degree Discipline: | 歯学 |
| Examination Committee Members: | (主査) 教授 舩橋 誠, 教授 飯村 忠浩, 教授 ⼭本 恒之 |
| Degree Affiliation: | 歯学院（口腔医学専攻） |
| (Relation)isversionof: | Su S, Fujita M, Wei Z, Huang H, Yoshizawa T, Inui T, Funahashi M. Effects of area postrema lesions and bilateral subdiaphragmatic afferent vagotomy on emetine-induced conditioned taste avoidance in rats. Physiol Behav. 2021 Nov 1;241:113565. doi: 10.1016/j.physbeh.2021.113565. Epub 2021 Aug 27. | | https://doi.org/10.1016/j.physbeh.2021.113565 |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/89389 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 歯学院(Graduate School of Dental Medicine)
学位論文 (Theses) > 博士 （歯学）
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