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Dynamic Control of Microbial Movement by Photoswitchable ATP Antagonists
| Title: | Dynamic Control of Microbial Movement by Photoswitchable ATP Antagonists |
| Authors: | Thayyil, Sampreeth Browse this author | | Nishigami, Yukinori Browse this author | | Islam, Md Jahirul Browse this author | | Hashim, P. K. Browse this author | | Furuta, Ken'ya Browse this author | | Oiwa, Kazuhiro Browse this author | | Yu, Jian Browse this author | | Yao, Min Browse this author | | Nakagaki, Toshiyuki Browse this author | | Tamaoki, Nobuyuki Browse this author →KAKEN DB |
| Keywords: | azobenzene | | ATP antagonist | | dynein | | motor protein | | photocontrol |
| Issue Date: | 25-May-2022 |
| Publisher: | Wiley-Blackwell |
| Journal Title: | Chemistry-A European journal |
| Volume: | 28 |
| Issue: | 30 |
| Start Page: | e202200807 |
| Publisher DOI: | 10.1002/chem.202200807 |
| Abstract: | Adenosine triphosphate (ATP) is the energy source for various biochemical processes and biomolecular motors in living things. Development of ATP antagonists and their stimuli-controlled actions offer a novel approach to regulate biological processes. Herein, we developed azobenzene-based photoswitchable ATP antagonists for controlling the activity of motor proteins; cytoplasmic and axonemal dyneins. The new ATP antagonists showed reversible photoswitching of cytoplasmic dynein activity in an in vitro dynein-microtubule system due to the trans and cis photoisomerization of their azobenzene segment. Importantly, our ATP antagonists reversibly regulated the axonemal dynein motor activity for the force generation in a demembranated model of Chlamydomonas reinhardtii. We found that the trans and cis isomers of ATP antagonists significantly differ in their affinity to the ATP binding site. |
| Rights: | This is the peer reviewed version of the following article: [S. Thayyil, Y. Nishigami, M. J. Islam, P. K. Hashim, K.'y. Furuta, K. Oiwa, J. Yu, M. Yao, T. Nakagaki, N. Tamaoki, Chem. Eur. J. 2022, 28, e202200807.], which has been published in final form at [https://doi.org/10.1002/chem.202200807]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/89537 |
| Appears in Collections: | 電子科学研究所 (Research Institute for Electronic Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 玉置 信之
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