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The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression

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Title: The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression
Authors: Gulay, Kevin Christian M. Browse this author
Aoshima, Keisuke Browse this author
Kim, Sangho Browse this author
Kitaguchi, Ryusei Browse this author
Kobayashi, Atsushi Browse this author
Kimura, Takashi Browse this author →KAKEN DB
Keywords: canine hemangiosarcoma
disease progression
patient profile
Issue Date: 20-Dec-2021
Publisher: John Wiley & Sons
Journal Title: Veterinary and comparative oncology
Volume: 20
Issue: 2
Start Page: 529
End Page: 534
Publisher DOI: 10.1111/vco.12796
Abstract: Canine hemangiosarcoma (HSA), a highly fatal mesenchymal tumour of dogs, originates from the endothelial cells lining of blood vessels. It is characterized by a short survival time with a mean survival time of only 4 months. Recently, we showed that histone lysine demethylase 2B (KDM2B) was highly expressed in canine HSA and was important in HSA tumour cell survival by positively regulating DNA repair mechanisms. KDM2B has been reported to be related to disease progression and patient survival in several human cancers. Thus, in this study, we studied the relationship of KDM2B expression levels with several patient clinical profiles to investigate the role of KDM2B in clinical HSA tumours. We analysed 37 canine HSA cases and found that KDM2B is highly expressed in stage 3 HSA compared to stage 1 HSA. High KDM2B expression was also found in male dogs compared to female dogs. No correlation was observed between KDM2B expression and age. Classifying HSA patients into high and low KDM2B expression groups revealed that the high KDM2B group showed shorter overall survival than the low KDM2B group. Based on these results, we suggest that KDM2B expression is associated with disease progression in HSA.
Rights: This is the peer reviewed version of the following article: Gulay, KCM, Aoshima, K, Kim, S, Kitaguchi, R, Kobayashi, A, Kimura, T. The expression of histone lysine demethylase 2B in canine hemangiosarcoma is associated with disease progression. Vet Comp Oncol. 2022; 20(2): 529-534., which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 青島 圭佑

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