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Outcomes of laparoscopic total gastrectomy in elderly patients : a propensity score matching analysis

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Title: Outcomes of laparoscopic total gastrectomy in elderly patients : a propensity score matching analysis
Authors: Ebihara, Yuma Browse this author →KAKEN DB
Kurashima, Yo Browse this author →KAKEN DB
Watanabe, Yusuke Browse this author
Tanaka, Kimitaka Browse this author →KAKEN DB
Matsui, Aya Browse this author →KAKEN DB
Nakanishi, Yoshitsugu Browse this author
Asano, Toshimichi Browse this author
Noji, Takehiro Browse this author →KAKEN DB
Nakamura, Toru Browse this author
Murakami, Soichi Browse this author
Tsuchikawa, Takahiro Browse this author →KAKEN DB
Okamura, Keisuke Browse this author
Murakami, Yoshihiro Browse this author
Murakawa, Katsuhiko Browse this author
Nakamura, Fumitaka Browse this author
Morita, Takayuki Browse this author
Okushiba, Shunichi Browse this author
Shichinohe, Toshiaki Browse this author →KAKEN DB
Hirano, Satoshi Browse this author →KAKEN DB
Keywords: Laparoscopic total gastrectomy
Gastric cancer
Elderly patients
Multicenter retrospective study
Issue Date: 1-Jun-2022
Publisher: Springer
Journal Title: Langenbeck's archives of surgery
Volume: 407
Issue: 4
Start Page: 1461
End Page: 1469
Publisher DOI: 10.1007/s00423-022-02447-2
Abstract: Purpose This study evaluated the short-term outcomes and prognosis after laparoscopic total gastrectomy (LTG) in elderly patients aged >= 80 years in a multicenter retrospective cohort study using propensity score matching. Methods We retrospectively enrolled 440 patients who underwent curative LTG for gastric cancer at six institutions between January 2004 and December 2018. Patients were categorized into an elderly patient group (EG; age >= 80 years) and non-elderly patient group (non-EG; age < 80 years). Patients were matched using the following propensity score covariates: sex, body mass index, American Society of Anesthesiologists physical status, extent of lymph node dissection, and Japanese Classification of Gastric Carcinoma stage. Short-term outcomes and prognoses were compared. Results We identified 37 propensity score-matched pairs. The median operative time was significantly shorter, and postoperative stay was longer in the EG. In terms of postoperative outcomes, the rates of all complications were comparable. The median follow-up period of the EG and non-EG was 11.5 (1-106.4) months and 35.7 (1-110.0) months, respectively; there were significant differences in 5-year overall survival between the two groups (EG, 58.5% vs. non-EG, 91.5%; P = 0.031). However, there were no significant differences in 5-year disease-specific survival (EG, 62.1% vs. non-EG, 91.5%; P = 0.068) or 5-year disease-free survival (EG, 52.9% vs. non-EG, 60.8%; P = 0.132). Conclusions LTG seems to be safe and feasible in elderly patients. LTG had a limited effect on morbidity, disease recurrence, and survival in elderly patients. Therefore, age should not prevent elderly patients from benefitting from LTG.
Rights: This is a post-peer-review, pre-copyedit version of an article published in Langenbeck's archives of surgery. The final authenticated version is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 海老原 裕磨

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