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Further evidence for association of YKL-40 with severe asthma airway remodeling

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Title: Further evidence for association of YKL-40 with severe asthma airway remodeling
Authors: Kimura, Hirokazu Browse this author →KAKEN DB
Shimizu, Kaoruko Browse this author →KAKEN DB
Tanabe, Naoya Browse this author
Makita, Hironi Browse this author
Taniguchi, Natsuko Browse this author
Kimura, Hiroki Browse this author
Suzuki, Masaru Browse this author
Abe, Yuki Browse this author
Matsumoto-Sasaki, Machiko Browse this author
Oguma, Akira Browse this author
Takimoto-Sato, Michiko Browse this author
Takei, Nozomu Browse this author
Matsumoto, Munehiro Browse this author
Goudarzi, Houman Browse this author
Sato, Susumu Browse this author
Ono, Junya Browse this author
Izuhara, Kenji Browse this author
Hirai, Toyohiro Browse this author
Nishimura, Masaharu Browse this author →KAKEN DB
Konno, Satoshi Browse this author →KAKEN DB
Issue Date: Jun-2022
Publisher: Elsevier
Journal Title: Annals of Allergy, Asthma & Immunology
Volume: 128
Issue: 6
Start Page: 682
End Page: 688.e5
Publisher DOI: 10.1016/j.anai.2022.03.016
Abstract: Background: The chitinase-like protein YKL-40 is associated with airflow limitation on spirometry and airway remodeling in patients with asthma. It remains unclear whether YKL-40 is associated with morphologic changes in the airways and parenchyma or with future progression of airflow limitation in severe asthma. Objective: To evaluate the association of circulating YKL-40 levels with morphologic changes in the airways and parenchyma and with longitudinal progression of airflow limitation. Methods: The patients were participants in the Hokkaido Severe Asthma Cohort Study (n = 127), including smokers. This study consisted of 2 parts. In analysis 1, we analyzed associations between circulating YKL-40 levels and several asthma-related indices, including computed tomography-derived indices of proximal wall area percentage, the complexity of the airways (airway fractal dimension), and the parenchyma (exponent D) crosssectionally (n = 97). In analysis 2, we evaluated the impact of circulating YKL-40 levels on forced expiratory volume in 1 second (FEV1) decline longitudinally for a 5-year follow-up (n = 103). Results: Circulating YKL-40 levels were significantly associated with proximal wall area percentage and airway fractal dimension (r = 0.25, P = .01; r = -0.22, P = .04, respectively), but not with exponent D. The mean annual change in FEV1 was -33.7 (+/- 23.3) mL/y, and the circulating YKL-40 level was a significant independent factor associated with annual FEV1 decline (beta = -0.24, P =.02), even after controlling for exponent D (beta = -0.26, P = .01). Conclusion: These results provide further evidence for the association of YKL-40 with the pathogenesis of airway remodeling in severe asthma. (C) 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Rights: © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木村 孔一

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