| Title: | Further evidence for association of YKL-40 with severe asthma airway remodeling |
| Authors: | Kimura, Hirokazu Browse this author →KAKEN DB |
| Shimizu, Kaoruko Browse this author →KAKEN DB |
| Tanabe, Naoya Browse this author |
| Makita, Hironi Browse this author |
| Taniguchi, Natsuko Browse this author |
| Kimura, Hiroki Browse this author |
| Suzuki, Masaru Browse this author |
| Abe, Yuki Browse this author |
| Matsumoto-Sasaki, Machiko Browse this author |
| Oguma, Akira Browse this author |
| Takimoto-Sato, Michiko Browse this author |
| Takei, Nozomu Browse this author |
| Matsumoto, Munehiro Browse this author |
| Goudarzi, Houman Browse this author |
| Sato, Susumu Browse this author |
| Ono, Junya Browse this author |
| Izuhara, Kenji Browse this author |
| Hirai, Toyohiro Browse this author |
| Nishimura, Masaharu Browse this author →KAKEN DB |
| Konno, Satoshi Browse this author →KAKEN DB |
| Issue Date: | Jun-2022 |
| Publisher: | Elsevier |
| Journal Title: | Annals of Allergy, Asthma & Immunology |
| Volume: | 128 |
| Issue: | 6 |
| Start Page: | 682 |
| End Page: | 688.e5 |
| Publisher DOI: | 10.1016/j.anai.2022.03.016 |
| Abstract: | Background: The chitinase-like protein YKL-40 is associated with airflow limitation on spirometry and airway remodeling in patients with asthma. It remains unclear whether YKL-40 is associated with morphologic changes in the airways and parenchyma or with future progression of airflow limitation in severe asthma. Objective: To evaluate the association of circulating YKL-40 levels with morphologic changes in the airways and parenchyma and with longitudinal progression of airflow limitation. Methods: The patients were participants in the Hokkaido Severe Asthma Cohort Study (n = 127), including smokers. This study consisted of 2 parts. In analysis 1, we analyzed associations between circulating YKL-40 levels and several asthma-related indices, including computed tomography-derived indices of proximal wall area percentage, the complexity of the airways (airway fractal dimension), and the parenchyma (exponent D) crosssectionally (n = 97). In analysis 2, we evaluated the impact of circulating YKL-40 levels on forced expiratory volume in 1 second (FEV1) decline longitudinally for a 5-year follow-up (n = 103). Results: Circulating YKL-40 levels were significantly associated with proximal wall area percentage and airway fractal dimension (r = 0.25, P = .01; r = -0.22, P = .04, respectively), but not with exponent D. The mean annual change in FEV1 was -33.7 (+/- 23.3) mL/y, and the circulating YKL-40 level was a significant independent factor associated with annual FEV1 decline (beta = -0.24, P =.02), even after controlling for exponent D (beta = -0.26, P = .01). Conclusion: These results provide further evidence for the association of YKL-40 with the pathogenesis of airway remodeling in severe asthma. (C) 2022 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved. |
| Rights: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/89790 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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