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Impact of citrus fruit intake on the mental health of patients with chronic heart failure

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Title: Impact of citrus fruit intake on the mental health of patients with chronic heart failure
Authors: Kakutani, Naoya Browse this author
Yokota, Takashi Browse this author →KAKEN DB
Fukushima, Arata Browse this author
Obata, Yoshikuni Browse this author
Ono, Taisuke Browse this author
Sota, Takeshi Browse this author
Kinugasa, Yoshiharu Browse this author
Takahashi, Masashige Browse this author
Matsuo, Hisashi Browse this author
Matsukawa, Ryuichi Browse this author
Yoshida, Ichiro Browse this author
Kakinoki, Shigeo Browse this author
Yonezawa, Kazuya Browse this author
Himura, Yoshihiro Browse this author
Yokota, Isao Browse this author →KAKEN DB
Yamamoto, Kazuhiro Browse this author
Tsuchihashi-Makaya, Miyuki Browse this author
Kinugawa, Shintaro Browse this author
Keywords: Antioxidant
Chronic heart failure
Citrus fruits
Oxidative stress
Vitamin C
Issue Date: Jun-2022
Publisher: Elsevier
Journal Title: Journal of cardiology
Volume: 79
Issue: 6
Start Page: 719
End Page: 726
Publisher DOI: 10.1016/j.jjcc.2021.12.004
Abstract: Background: The full impact of the intake of citrus fruits on the risk of depression in individuals with chronic heart failure (HF) is unknown. Here, we examined the associations between the estimated habitual intakes of citrus fruits and depressive symptoms in patients with chronic HF. Methods: We enrolled 150 stable outpatients with chronic HF who had a history of worsening HF. To assess the patients' daily dietary patterns, we used a brief self-administered diet-history questionnaire to calculate the daily consumption of foods and nutrients. To assess the patients' mental state, we used a nine-item Patient Health Questionnaire (PHQ-9). Results: Twelve patients (8%) were identified as having moderate-to-severe depression (PHQ-9 score > 10). The patients with PHQ-9 > 10 had lower daily intakes of citrus fruits compared to those with no or mild depressive symptoms (PHQ-9 < 10). The daily intakes of various antioxidants, including vitamin C, beta- carotene, and beta-cryptoxanthin, all of which are abundant in citrus fruits, were reduced in the patients with PHQ-9 > 10, accompanied by higher serum levels of 8-isoprostane (an oxidative stress marker). A multivariate logistic regression analysis using forward selection showed that a lowered daily intake of citrus fruits was an independent predictor of the comorbidity of moderate-to-severe depression in patients with chronic HF, after adjustment for age, gender, and the hemoglobin value. Conclusions: A lower daily consumption of citrus fruits was associated with higher prevalence of depression in patients with chronic HF. Our findings support the hypothesis that a daily consumption of citrus fruits has a beneficial effect on the prevention and treatment of depression in chronic HF patients. (C)2021 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 横田 卓

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