| Title: | Impact of citrus fruit intake on the mental health of patients with chronic heart failure |
| Authors: | Kakutani, Naoya Browse this author |
| Yokota, Takashi Browse this author →KAKEN DB |
| Fukushima, Arata Browse this author |
| Obata, Yoshikuni Browse this author |
| Ono, Taisuke Browse this author |
| Sota, Takeshi Browse this author |
| Kinugasa, Yoshiharu Browse this author |
| Takahashi, Masashige Browse this author |
| Matsuo, Hisashi Browse this author |
| Matsukawa, Ryuichi Browse this author |
| Yoshida, Ichiro Browse this author |
| Kakinoki, Shigeo Browse this author |
| Yonezawa, Kazuya Browse this author |
| Himura, Yoshihiro Browse this author |
| Yokota, Isao Browse this author →KAKEN DB |
| Yamamoto, Kazuhiro Browse this author |
| Tsuchihashi-Makaya, Miyuki Browse this author |
| Kinugawa, Shintaro Browse this author |
| Keywords: | Antioxidant |
| Chronic heart failure |
| Citrus fruits |
| Depression |
| Oxidative stress |
| Vitamin C |
| beta-carotene |
| beta-cryptoxanthin |
| Issue Date: | Jun-2022 |
| Publisher: | Elsevier |
| Journal Title: | Journal of cardiology |
| Volume: | 79 |
| Issue: | 6 |
| Start Page: | 719 |
| End Page: | 726 |
| Publisher DOI: | 10.1016/j.jjcc.2021.12.004 |
| Abstract: | Background: The full impact of the intake of citrus fruits on the risk of depression in individuals with chronic heart failure (HF) is unknown. Here, we examined the associations between the estimated habitual intakes of citrus fruits and depressive symptoms in patients with chronic HF. Methods: We enrolled 150 stable outpatients with chronic HF who had a history of worsening HF. To assess the patients' daily dietary patterns, we used a brief self-administered diet-history questionnaire to calculate the daily consumption of foods and nutrients. To assess the patients' mental state, we used a nine-item Patient Health Questionnaire (PHQ-9). Results: Twelve patients (8%) were identified as having moderate-to-severe depression (PHQ-9 score > 10). The patients with PHQ-9 > 10 had lower daily intakes of citrus fruits compared to those with no or mild depressive symptoms (PHQ-9 < 10). The daily intakes of various antioxidants, including vitamin C, beta- carotene, and beta-cryptoxanthin, all of which are abundant in citrus fruits, were reduced in the patients with PHQ-9 > 10, accompanied by higher serum levels of 8-isoprostane (an oxidative stress marker). A multivariate logistic regression analysis using forward selection showed that a lowered daily intake of citrus fruits was an independent predictor of the comorbidity of moderate-to-severe depression in patients with chronic HF, after adjustment for age, gender, and the hemoglobin value. Conclusions: A lower daily consumption of citrus fruits was associated with higher prevalence of depression in patients with chronic HF. Our findings support the hypothesis that a daily consumption of citrus fruits has a beneficial effect on the prevention and treatment of depression in chronic HF patients. (C)2021 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
| Rights: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/89792 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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