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Comparison of the virulence of Candida albicans strains on oral candidiasis and non-oral candidiasis.
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| Title: | Comparison of the virulence of Candida albicans strains on oral candidiasis and non-oral candidiasis. |
| Other Titles: | 口腔カンジダ症由来株と非口腔カンジダ症由来株のCandida albicans の病原性の比較 |
| Authors: | 大内, 千里 Browse this author |
| Issue Date: | 23-Mar-2023 |
| Publisher: | Hokkaido University |
| Abstract: | Objective Oral candidiasis is an opportunistic infection caused by the fungus Candida. The underlying cause of candidiasis is therefore more likely to be host factors than the presence of the fungus. However, the pathogenicity of the fungus may also be important. We therefore hypothesised that the pathogenicity of Candida albicans may be different between strains, and aimed to compare the differences of virulence. Materials and Mehotds Candida albicans from patients who visited the Hokkaido University Hospital Dental Centre and were tested for Candida to i) identify the Candida albicans genotype by PCR, ii) measure the strain’s extracellular secretory enzyme activity, iii) determine the strain’s ability to induce the production of interleukin-8, and iv) determine the strain’s ability to induce cell death. Results We found that certain virulence-related activities were higher in strains derived from patients with oral candidiasis compared with strains derived from patients without oral candidiasis. Conclusion These results suggest that differences in the virulence of the fungal strain may influence the pathogenesis of oral candidiasis. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第15500号 |
| Degree Level: | 博士 |
| Degree Discipline: | 歯学 |
| Examination Committee Members: | (主査) 教授 長谷部 晃, 教授 北川 善政, 教授 山崎 裕, |
| Degree Affiliation: | 歯学院（口腔医学専攻） |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/89918 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 歯学院(Graduate School of Dental Medicine)
学位論文 (Theses) > 博士 （歯学）
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