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Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2
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| Title: | Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2 |
| Other Titles: | 洗口液中成分セチルピリジニウム塩化物水和物のSARS-CoV-2に対する抗ウイルス効果 |
| Authors: | 武田, 遼 Browse this author |
| Issue Date: | 23-Mar-2023 |
| Publisher: | Hokkaido University |
| Abstract: | Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is efective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral efect of CPC on SARS-CoV-2. There are few reports on the efect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%-0.005% (10-50 μg/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 efects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第15504号 |
| Degree Level: | 博士 |
| Degree Discipline: | 歯学 |
| Examination Committee Members: | (主査) 教授 樋田 京子, 教授 北川 善政, 教授 大廣 洋一 |
| Degree Affiliation: | 歯学院（口腔医学専攻） |
| (Relation)isversionof: | Takeda, R., Sawa, H., Sasaki, M. et al. Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2. Sci Rep 12, 14050 (2022). | | https://doi.org/10.1038/s41598-022-18367-6 |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/89929 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 歯学院(Graduate School of Dental Medicine)
学位論文 (Theses) > 博士 （歯学）
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