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The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation
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| Title: | The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation |
| Other Titles: | 口腔細菌, Streptococcus mutansは、血管炎症を誘発し転移を促進する |
| Authors: | Yu, Li Browse this author |
| Keywords: | endothelial cells | | oral bacteria | | oral hygiene | | tumor metastasis | | vascular inflammation |
| Issue Date: | 23-Mar-2023 |
| Publisher: | Hokkaido University |
| Abstract: | Recent studies have demonstrated a relationship between oral bacteria and systemic inflammation. Endothelial cells (ECs), which line blood vessels, control the opening and closing of the vascular barrier and contribute to hematogenous metastasis; however, the role of oral bacteria-induced vascular inflammation in tumor metastasis remains unclear. In this study, we examined the phenotypic changes in vascular ECs following Streptococcus mutans (S. mutans) stimulation in vitro and in vivo. The expression of molecules associated with vascular inflammation and barrier-associated adhesion was analyzed. Tumor metastasis was evaluated after intravenous injection of S. mutans in murine breast cancer hematogenous metastasis model. The results indicated that S. mutans invaded the ECs accompanied by inflammation and NF-κB activation. S. mutans exposure potentially disrupts endothelial integrity by decreasing vascular endothelial (VE)-cadherin expression. The migration and adhesion of tumor cells were enhanced in S. mutans-stimulated ECs. Furthermore, S. mutans-induced lung vascular inflammation promoted breast cancer cell metastasis to the lungs in vivo. The results indicate that oral bacteria promote tumor metastasis through vascular inflammation and the disruption of vascular barrier function. Improving oral hygiene in patients with cancer is of great significance in preventing postoperative pneumonia and tumor metastasis. |
| Conffering University: | 北海道大学 |
| Degree Report Number: | 甲第15507号 |
| Degree Level: | 博士 |
| Degree Discipline: | 歯学 |
| Examination Committee Members: | (主査) 教授 樋田 京子, 教授 北川 善政, 教授 長谷部 晃 |
| Degree Affiliation: | 歯学院（口腔医学専攻） |
| (Relation)isversionof: | Yu L, Maishi N, Akahori E, Hasebe A, Takeda R, Matsuda AY, Hida Y, Nam JM, Onodera Y, Kitagawa Y, Hida K. The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation. Cancer Sci. 2022 Nov;113(11):3980-3994. | | https://doi.org/10.1111/cas.15538 |
| Type: | theses (doctoral) |
| URI: | http://hdl.handle.net/2115/89932 |
| Appears in Collections: | 課程博士 (Doctorate by way of Advanced Course) > 歯学院(Graduate School of Dental Medicine)
学位論文 (Theses) > 博士 （歯学）
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