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Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic/epigenetic mutation and microenvironment

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Title: Glioblastoma-initiating cell heterogeneity generated by the cell-of-origin, genetic/epigenetic mutation and microenvironment
Authors: Kondo, Toru Browse this author →KAKEN DB
Keywords: Glioblastoma (GBM)
GBM-initiating cells (GICs)
Temozolomide (TMZ)
Dihydroorotate dehydrogenase (DHODH)
Issue Date: 1-Jul-2022
Publisher: Elsevier
Journal Title: Seminars in Cancer Biology
Volume: 82
Start Page: 176
End Page: 183
Publisher DOI: 10.1016/j.semcancer.2020.12.003
Abstract: Glioblastoma (GBM) and other malignant tumours consist of heterogeneous cancer cells, including GBMinitiating cells (GICs). This heterogeneity is likely to arise from the following: different sets of genetic mutations and epigenetic modifications, which GICs gain in the transformation process; differences in cells of origin, such as stem cells, precursor cells or differentiated cells; and the cancer microenvironment, in which GICs communicate with neural cells, endothelial cells and immune cells. Furthermore, considering that various types of GICs can be generated at different time points of the transformation process, GBM very likely consists of heterogeneous GICs and their progeny. Because cancer cell heterogeneity is responsible for therapy resistance, it is crucial to develop methods of reducing such heterogeneity. Here, I summarize how GIC heterogeneity is generated in the transformation process and present how cell heterogeneity in cancer can be addressed based on recent findings.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 近藤 亨

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