| Title: | Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses |
| Authors: | Tabata, Koshiro Browse this author |
| Itakura, Yukari Browse this author |
| Toba, Shinsuke Browse this author |
| Uemura, Kentaro Browse this author |
| Kishimoto, Mai Browse this author |
| Sasaki, Michihito Browse this author →KAKEN DB |
| Harrison, Jessica J. Browse this author |
| Sato, Akihiko Browse this author |
| Hall, William W. Browse this author |
| Hall, Roy A. Browse this author |
| Sawa, Hirofumi Browse this author →KAKEN DB |
| Orba, Yasuko Browse this author →KAKEN DB |
| Keywords: | Lineage II insect-Specific flavivirus |
| BJV |
| PSFV |
| Antibody |
| Cross-reactivity |
| Antibody-dependent enhancement (ADE) |
| Issue Date: | 6-Aug-2022 |
| Publisher: | Elsevier |
| Journal Title: | Biochemical and biophysical research communications |
| Volume: | 616 |
| Start Page: | 115 |
| End Page: | 121 |
| Publisher DOI: | 10.1016/j.bbrc.2022.05.080 |
| Abstract: | The genus Flavivirus includes pathogenic tick- and mosquito-borne flaviviruses as well as non-pathogenic insect-specific flaviviruses (ISFVs). Phylogenetic analysis based on whole amino acid sequences has indicated that lineage II ISFVs have similarities to pathogenic flaviviruses. In this study, we used reactive analysis with immune serum against Psorophora flavivirus (PSFV) as a lineage IIa ISFV, and Barkeji virus (BJV) as a lineage IIb ISFV, to evaluate the antigenic similarity among lineage IIa and IIb ISFVs, and pathogenic mosquito-borne flaviviruses (MBFVs). Binding and antibody-dependent enhancement assays showed that anti-PSFV sera had broad cross-reactivity with MBFV antigens, while anti-BJV sera had low cross-reactivity. Both of the lineage II ISFV antisera were rarely observed to neutralize MBFVs. These results suggest that lineage IIa ISFV PSFV has more antigenic similarity to MBFVs than lineage IIb ISFV BJV. |
| Rights: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90263 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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