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Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses

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Title: Serological characterization of lineage II insect-specific flaviviruses compared with pathogenic mosquito-borne flaviviruses
Authors: Tabata, Koshiro Browse this author
Itakura, Yukari Browse this author
Toba, Shinsuke Browse this author
Uemura, Kentaro Browse this author
Kishimoto, Mai Browse this author
Sasaki, Michihito Browse this author →KAKEN DB
Harrison, Jessica J. Browse this author
Sato, Akihiko Browse this author
Hall, William W. Browse this author
Hall, Roy A. Browse this author
Sawa, Hirofumi Browse this author →KAKEN DB
Orba, Yasuko Browse this author →KAKEN DB
Keywords: Lineage II insect-Specific flavivirus
Antibody-dependent enhancement (ADE)
Issue Date: 6-Aug-2022
Publisher: Elsevier
Journal Title: Biochemical and biophysical research communications
Volume: 616
Start Page: 115
End Page: 121
Publisher DOI: 10.1016/j.bbrc.2022.05.080
Abstract: The genus Flavivirus includes pathogenic tick- and mosquito-borne flaviviruses as well as non-pathogenic insect-specific flaviviruses (ISFVs). Phylogenetic analysis based on whole amino acid sequences has indicated that lineage II ISFVs have similarities to pathogenic flaviviruses. In this study, we used reactive analysis with immune serum against Psorophora flavivirus (PSFV) as a lineage IIa ISFV, and Barkeji virus (BJV) as a lineage IIb ISFV, to evaluate the antigenic similarity among lineage IIa and IIb ISFVs, and pathogenic mosquito-borne flaviviruses (MBFVs). Binding and antibody-dependent enhancement assays showed that anti-PSFV sera had broad cross-reactivity with MBFV antigens, while anti-BJV sera had low cross-reactivity. Both of the lineage II ISFV antisera were rarely observed to neutralize MBFVs. These results suggest that lineage IIa ISFV PSFV has more antigenic similarity to MBFVs than lineage IIb ISFV BJV.
Rights: © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大場 靖子

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