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Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697

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Title: Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697
Authors: Phan, Chin-Soon Browse this author
Mehjabin, Jakia Jerin Browse this author
Anas, Andrea Roxanne J. Browse this author
Hayasaka, Masahiro Browse this author
Onoki, Reiko Browse this author
Wang, Juting Browse this author
Umezawa, Taiki Browse this author →KAKEN DB
Washio, Kenji Browse this author →KAKEN DB
Morikawa, Masaaki Browse this author →KAKEN DB
Okino, Tatsufumi Browse this author →KAKEN DB
Issue Date: 10-Aug-2022
Publisher: American Chemical Society
Journal Title: Journal of Natural Products
Volume: 85
Issue: 8
Start Page: 2000
End Page: 2005
Publisher DOI: 10.1021/acs.jnatprod.2c00382
Abstract: Chemical investigation of the cyanobacterium Dolichospermum sp. NIES-1697 afforded nostosin G (1), a linear tripeptide, spiroidesin B (2), and two known compounds, anabaenopeptins I (3) and J (4). Planar structures and absolute configurations for 1 and 2 were determined by 2D NMR, HRMS, Marfey's methodology, chiral-phase HPLC, and enzymatic degradation. Nostosin G (1) is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal, with potent trypsin inhibitory properties. The biosynthetic gene clusters for nostosin G (1) and spiroidesin B (2) were investigated based on the genome sequence of Dolichospermum sp. NIES-1697.
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Type: article (author version)
Appears in Collections:環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 沖野 龍文

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