| Title: | Nostosin G and Spiroidesin B from the Cyanobacterium Dolichospermum sp. NIES-1697 |
| Authors: | Phan, Chin-Soon Browse this author |
| Mehjabin, Jakia Jerin Browse this author |
| Anas, Andrea Roxanne J. Browse this author |
| Hayasaka, Masahiro Browse this author |
| Onoki, Reiko Browse this author |
| Wang, Juting Browse this author |
| Umezawa, Taiki Browse this author →KAKEN DB |
| Washio, Kenji Browse this author →KAKEN DB |
| Morikawa, Masaaki Browse this author →KAKEN DB |
| Okino, Tatsufumi Browse this author →KAKEN DB |
| Issue Date: | 10-Aug-2022 |
| Publisher: | American Chemical Society |
| Journal Title: | Journal of Natural Products |
| Volume: | 85 |
| Issue: | 8 |
| Start Page: | 2000 |
| End Page: | 2005 |
| Publisher DOI: | 10.1021/acs.jnatprod.2c00382 |
| Abstract: | Chemical investigation of the cyanobacterium Dolichospermum sp. NIES-1697 afforded nostosin G (1), a linear tripeptide, spiroidesin B (2), and two known compounds, anabaenopeptins I (3) and J (4). Planar structures and absolute configurations for 1 and 2 were determined by 2D NMR, HRMS, Marfey's methodology, chiral-phase HPLC, and enzymatic degradation. Nostosin G (1) is a unique example of a linear peptide containing three subunits, 4-hydroxyphenyllactic acid (Hpla), homotyrosine (Hty), and argininal, with potent trypsin inhibitory properties. The biosynthetic gene clusters for nostosin G (1) and spiroidesin B (2) were investigated based on the genome sequence of Dolichospermum sp. NIES-1697. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Natural Products, copyright c American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/full/10.1021/acs.jnatprod.2c00382. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90284 |
| Appears in Collections: | 環境科学院・地球環境科学研究院 (Graduate School of Environmental Science / Faculty of Environmental Earth Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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