| Title: | Various factors contribute to death in patients with different types of pulmonary hypertension : A retrospective pilot study from a single tertiary center |
| Authors: | Nakamura, Junichi Browse this author |
| Tsujino, Ichizo Browse this author →KAKEN DB |
| Ohira, Hiroshi Browse this author →KAKEN DB |
| Nakaya, Toshitaka Browse this author |
| Sugimoto, Ayako Browse this author |
| Sato, Takahiro Browse this author |
| Watanabe, Taku Browse this author |
| Suzuki, Masaru Browse this author →KAKEN DB |
| Kato, Masaru Browse this author |
| Yokota, Isao Browse this author →KAKEN DB |
| Konno, Satoshi Browse this author →KAKEN DB |
| Keywords: | Right heart failure |
| Sudden death |
| Cancer |
| Respiratory failure |
| Issue Date: | Sep-2022 |
| Publisher: | Elsevier |
| Journal Title: | Respiratory Investigation |
| Volume: | 60 |
| Issue: | 5 |
| Start Page: | 647 |
| End Page: | 657 |
| Publisher DOI: | 10.1016/j.resinv.2022.05.001 |
| Abstract: | Background: A few studies have focused on the cause of death from different types of pulmonary hypertension (PH). This study aimed to systematically analyze the primary and secondary causes of death and compare the profiles between different PH groups. Methods: The contribution of PH to death was assessed in precapillary PH (i.e., group 1 [pulmonary arterial hypertension], group 3 [PH associated with lung disease], and group 4 [chronic thromboembolic PH]) using specific criteria; death was classified into three categories: PH death (death due to PH only), PH-related death, and PH-unrelated death. Disorders other than PH that contributed to death were analyzed, and mortality profiles were compared between groups. Results: Eighty deceased patients with PH were examined (group 1, n = 28; group 3, n = 39; and group 4, n = 13). The contribution of PH to death was significantly different between the three groups. PH death was most common in group 1 (61%), PH-related death in group 3 (56%), and PH-related death and PH-unrelated death in group 4 (38% for both). The highest contributing factor to death other than PH was respiratory failure in group 3 and malignant disease in group 4. Conclusions: Significant variations in the causes of death were observed in groups 1, 3, and 4 PH patients. In addition to PH, respiratory failure and malignant disease significantly contributed to death in group 3 and group 4 PH, respectively. Understanding the precise death cause may be important in achieving better outcomes in PH patients. (C) 2022 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved. |
| Rights: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90333 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
