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Hokkaido University Collection of Scholarly and Academic Papers >
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Antioxidant and fibroblast-activating activities of the by-product of skate chondroitin extractive production
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| Title: | Antioxidant and fibroblast-activating activities of the by-product of skate chondroitin extractive production |
| Authors: | Li, Wen Browse this author | | Terauchi, Naoya Browse this author | | Meng, Dawei Browse this author | | Miyamoto, Nobuyuki Browse this author | | Tsutsumi, Naonobu Browse this author | | Ura, Kazuhiro Browse this author →KAKEN DB | | Takagi, Yasuaki Browse this author →KAKEN DB |
| Keywords: | By-product | | Wound-healing promoter | | Type II collagen peptide | | Chondroitin sulfate polysaccharide |
| Issue Date: | Oct-2021 |
| Publisher: | Elsevier |
| Journal Title: | Sustainable Chemistry and Pharmacy |
| Volume: | 23 |
| Start Page: | 100499 |
| Publisher DOI: | 10.1016/j.scp.2021.100499 |
| Abstract: | Owing to the increasing popularity of chondroitin sulfate (CS) for joint pain treatment, the CS-production industry has been producing an increasing amount of waste, which includes type II collagen, non-collagenous proteins, and residual CS. To effectively utilize these resources, we intended to develop new products from the by-product of skate chondroitin sulfate production (BP-sCS). In this study, we examined the antioxidant and fibroblast-activating properties of BP-sCS, intending to apply it for a wound-healing promoter. BP-sCS exhibited ABTS and DPPH radical scavenging activities, protected L929 fibroblasts from H2O2- or AAPH-induced oxidative stress, and scavenged intracellular reactive oxygen species. Moreover, BP-sCS promoted L929 fibroblast proliferation/metabolism and stimulated collagen deposition into the extracellular matrix. In addition, BP-sCS counteracted AAPH-induced oxidative stress damage that inhibited fibroblast migration. These effect were attributed to the cooperation among the molecules of BP-sCS, namely, type II collagen peptides, non-collagenous peptides, and CS polysaccharides. Our findings indicate that BP-sCS has the potential as a novel wound-healing promoter. This study is the first step toward the realization of a sustainable CS-production industry by waste utilization in healthcare products. |
| Rights: | © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90463 |
| Appears in Collections: | 水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 都木 靖彰
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