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Antioxidant and fibroblast-activating activities of the by-product of skate chondroitin extractive production

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Title: Antioxidant and fibroblast-activating activities of the by-product of skate chondroitin extractive production
Authors: Li, Wen Browse this author
Terauchi, Naoya Browse this author
Meng, Dawei Browse this author
Miyamoto, Nobuyuki Browse this author
Tsutsumi, Naonobu Browse this author
Ura, Kazuhiro Browse this author →KAKEN DB
Takagi, Yasuaki Browse this author →KAKEN DB
Keywords: By-product
Wound-healing promoter
Type II collagen peptide
Chondroitin sulfate polysaccharide
Issue Date: Oct-2021
Publisher: Elsevier
Journal Title: Sustainable Chemistry and Pharmacy
Volume: 23
Start Page: 100499
Publisher DOI: 10.1016/j.scp.2021.100499
Abstract: Owing to the increasing popularity of chondroitin sulfate (CS) for joint pain treatment, the CS-production industry has been producing an increasing amount of waste, which includes type II collagen, non-collagenous proteins, and residual CS. To effectively utilize these resources, we intended to develop new products from the by-product of skate chondroitin sulfate production (BP-sCS). In this study, we examined the antioxidant and fibroblast-activating properties of BP-sCS, intending to apply it for a wound-healing promoter. BP-sCS exhibited ABTS and DPPH radical scavenging activities, protected L929 fibroblasts from H2O2- or AAPH-induced oxidative stress, and scavenged intracellular reactive oxygen species. Moreover, BP-sCS promoted L929 fibroblast proliferation/metabolism and stimulated collagen deposition into the extracellular matrix. In addition, BP-sCS counteracted AAPH-induced oxidative stress damage that inhibited fibroblast migration. These effect were attributed to the cooperation among the molecules of BP-sCS, namely, type II collagen peptides, non-collagenous peptides, and CS polysaccharides. Our findings indicate that BP-sCS has the potential as a novel wound-healing promoter. This study is the first step toward the realization of a sustainable CS-production industry by waste utilization in healthcare products.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:水産科学院・水産科学研究院 (Graduate School of Fisheries Sciences / Faculty of Fisheries Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 都木 靖彰

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