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Lead concentrations and isotope ratios in blood, breastmilk and feces : contribution of both lactation and soil/dust exposure to infants in a lead

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Title: Lead concentrations and isotope ratios in blood, breastmilk and feces : contribution of both lactation and soil/dust exposure to infants in a lead
Authors: Toyomaki, Haruya Browse this author
Yabe, John Browse this author
Nakayama, Shouta M. M. Browse this author →KAKEN DB
Yohannes, Yared B. Browse this author
Muzandu, Kaampwe Browse this author
Mufune, Tiza Browse this author
Nakata, Hokuto Browse this author →KAKEN DB
Ikenaka, Yoshinori Browse this author →KAKEN DB
Kuritani, Takeshi Browse this author
Nakagawa, Mitsuhiro Browse this author →KAKEN DB
Choongo, Kennedy Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: Lead poisoning
Lead stable isotope
Issue Date: 1-Oct-2021
Publisher: Elsevier
Journal Title: Environmental pollution
Volume: 286
Start Page: 117456
Publisher DOI: 10.1016/j.envpol.2021.117456
Abstract: Lead (Pb) poses a serious public health concern. Breastmilk may be a possible source of Pb exposure in infants, as Pb can be transferred from the maternal blood to breastmilk. The present study was undertaken to determine the Pb exposure and the contribution of lactation as one of the exposure pathways to infants in a Pb mining area, Kabwe, Zambia. Blood, breastmilk and infants' feces were collected from 418 pairs of infants and mothers. The Pb concentrations, isotope ratios in the samples, and biochemistry in mothers' plasma were analyzed. The overall mean of blood lead levels (BLLs) in infants and mothers were 18.0 and 11.3 mu g/dL, respectively. High Pb concentration in breastmilk (range: 0.4-51.9, mean: 5.3 mu g/L) above the WHO acceptable level between 2 and 5 mu g/ L were found and could be one of the sources of Pb exposure in infants. The Pb isotope ratios in infants' feces were the most similar to Pb ratios in the soil samples. The results suggest that infants are also exposed to Pb from the environment. Pb exposure in infants through breastfeeding and soil ingestion could potentially exceed daily intake of Pb which causes neurodevelopmental toxicity. In contrast to the high BLLs in mothers, the plasma biochemical profiles of most analyzed parameters were interestingly within, or close to, the standard reference values. Our data suggest that environmental remediation is urgently needed to reduce the Pb exposure in infants and mothers from the environment in Kabwe in parallel with chelation therapy.
Rights: © 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 中山 翔太

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