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Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases
This item is licensed under:Creative Commons Attribution 4.0 International
| Title: | Cross-disease communication between cancer and heart failure provides a rational approach to prevention and treatment of both diseases |
| Authors: | Takada, Shingo Browse this author | | Kinugawa, Shintaro Browse this author | | Handa, Haruka Browse this author | | Yokota, Takashi Browse this author | | Sabe, Hisataka Browse this author →KAKEN DB |
| Issue Date: | 31-Oct-2022 |
| Publisher: | Frontiers Media |
| Journal Title: | Frontiers in Oncology |
| Volume: | 12 |
| Start Page: | 1006322 |
| Publisher DOI: | 10.3389/fonc.2022.1006322 |
| Abstract: | Accumulating clinical data have demonstrated a clear positive association between cancer and cardiac disorders, particularly chronic heart failure (CHF). These two diseases can be mutual drivers of each other, and hence frequently co-occur in patients. The immune system is the core mechanism that eliminates transformed cells from our bodies. However, immune cells often play distinct or even conflicting roles in cancer and CHF. Moreover, CHF alters the properties of immune cells, particularly those of regulatory T cells. Our previous study showed that the oxidative phosphorylation capacity of peripheral blood mononuclear cells is impaired in CHF, leading to the increased production of reactive oxygen species. Therefore, the co-occurrence of cancer and CHF becomes a serious problem, affecting the treatment of both diseases, and consequently negatively affecting patient survival rates. To date, few methods have been identified that effectively treat both diseases at the same time. Mitochondria activity may change in immune cells during their activation and exhaustion, and in CHF. Mitochondria activity is also largely affected in myocardia in CHF. We here focus on the mitochondrial abnormalities of immune cells in cancer and CHF, and discuss possible ways to treat cancer and CHF at the same time by targeting mitochondrial abnormalities. Many cancer cells are inevitably produced daily in our bodies, mostly owing to enzymatic nucleotide errors of DNA replication and repair. Therefore, the possibility of ways to prevent cancer by preventing the onset of heart failure will also be discussed. |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/90515 |
| Appears in Collections: | 遺伝子病制御研究所 (Institute for Genetic Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 佐邊 壽孝
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