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Hokkaido University Collection of Scholarly and Academic Papers >
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Age Difference of the Relationship Between Cerebral Oxygen Saturation and Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass : Analysis Using the Random-Effects Model
| Title: | Age Difference of the Relationship Between Cerebral Oxygen Saturation and Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass : Analysis Using the Random-Effects Model |
| Authors: | Yamamoto, Masataka Browse this author | | Toki, Takayuki Browse this author | | Kubo, Yasunori Browse this author | | Hoshino, Koji Browse this author | | Morimoto, Yuji Browse this author →KAKEN DB |
| Keywords: | Cerebral oxygen saturation | | Pediatric cardiac surgery | | Cardiopulmonary bypass | | Random-effects model | | Cerebral autoregulation | | Age |
| Issue Date: | 1-Oct-2022 |
| Publisher: | Springer |
| Journal Title: | Pediatric cardiology |
| Volume: | 43 |
| Issue: | 7 |
| Start Page: | 1606 |
| End Page: | 1614 |
| Publisher DOI: | 10.1007/s00246-022-02889-x |
| Abstract: | Recently, monitoring of cerebral oxygen saturation (ScO2) has become widespread in pediatric cardiac surgery. Our previous study reported that mean blood pressure (mBP) was the major contributor to ScO2 throughout cardiac surgery with cardiopulmonary bypass (CPB) in children weighing under 10 kg. We speculated that this result might be attributable to incomplete cerebral autoregulation in such young children. Accordingly, our hypothesis is that the relationship between ScO2 and the physiological parameters may change according to the growth of the children. ScO2 was measured with an INVOS 5100C (Somanetics, Troy, MI). Random-effects analysis was employed with ScO2 as a dependent variable, and seven physiological parameters (mBP, central venous pressure, nasopharyngeal temperature, SaO(2), hematocrit, PaCO2, and pH) were entered as independent covariates. The analysis was performed during the pre-CPB, CPB, and post-CPB periods by dividing the patients into two groups: infants (Infant Group) and children who were more than 1 year old (Child Group). The Infant and Child Groups consisted of 28 and 21 patients. In the random-effects analysis, mBP was the major contributor to ScO2 during CPB in both groups. During the pre-CPB period, the effect of mBP was strongest in the Infant group. However, its effect was second to that of SaO(2) in the Child Group. During the post-CPB period, SaO(2) and mBP still affected ScO2 in the Infant group. However, the dominant contributors were unclear in the Child Group. Cerebral autoregulation may be immature in infants. In addition, it may be impaired during CPB even after 1 year of age. |
| Rights: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00246-022-02889-x |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90586 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 森本 裕二
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