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Isolation and characterization of an orthoreovirus from Indonesian fruit bats

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Title: Isolation and characterization of an orthoreovirus from Indonesian fruit bats
Authors: Intaruck, Kittiya Browse this author
Itakura, Yukari Browse this author
Kishimoto, Mai Browse this author
Chambaro, Herman M. Browse this author
Setiyono, Agus Browse this author
Handharyani, Ekowati Browse this author
Uemura, Kentaro Browse this author
Harima, Hayato Browse this author
Taniguchi, Satoshi Browse this author
Saijo, Masayuki Browse this author
Kimura, Takashi Browse this author
Orba, Yasuko Browse this author →KAKEN DB
Sawa, Hirofumi Browse this author →KAKEN DB
Sasaki, Michihito Browse this author →KAKEN DB
Keywords: Orthoreovirus
Nelson bay orthoreovirus
Fruit bats
Virus isolation
Viral pathogenicity
Issue Date: Oct-2022
Publisher: Elsevier
Journal Title: Virology
Volume: 575
Start Page: 10
End Page: 19
Publisher DOI: 10.1016/j.virol.2022.08.003
Abstract: Nelson Bay orthoreovirus (NBV) is an emerging bat-borne virus and causes respiratory tract infections in humans sporadically. Over the last two decades, several strains genetically related to NBV were isolated from humans and various bat species, predominantly in Southeast Asia (SEA), suggesting a high prevalence of the NBV species in this region. In this study, an orthoreovirus (ORV) belonging to the NBV species was isolated from Indonesian fruit bats' feces, tentatively named Paguyaman orthoreovirus (PgORV). Serological studies revealed that 81.2% (108/ 133) of Indonesian fruit bats sera had neutralizing antibodies against PgORV. Whole-genome sequencing and phylogenetic analysis of PgORV suggested the occurrence of past reassortments with other NBV strains isolated in SEA, indicating the dispersal and circulation of NBV species among bats in this region. Intranasal PgORV inoculation of laboratory mice caused severe pneumonia. Our study characterized PgORV's unique genetic background and highlighted the potential risk of PgORV-related diseases in Indonesia.
Rights: © 2002. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐々木 道仁

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