| Title: | Isolation and characterization of an orthoreovirus from Indonesian fruit bats |
| Authors: | Intaruck, Kittiya Browse this author |
| Itakura, Yukari Browse this author |
| Kishimoto, Mai Browse this author |
| Chambaro, Herman M. Browse this author |
| Setiyono, Agus Browse this author |
| Handharyani, Ekowati Browse this author |
| Uemura, Kentaro Browse this author |
| Harima, Hayato Browse this author |
| Taniguchi, Satoshi Browse this author |
| Saijo, Masayuki Browse this author |
| Kimura, Takashi Browse this author |
| Orba, Yasuko Browse this author →KAKEN DB |
| Sawa, Hirofumi Browse this author →KAKEN DB |
| Sasaki, Michihito Browse this author →KAKEN DB |
| Keywords: | Orthoreovirus |
| Nelson bay orthoreovirus |
| Indonesia |
| Fruit bats |
| Virus isolation |
| Viral pathogenicity |
| Issue Date: | Oct-2022 |
| Publisher: | Elsevier |
| Journal Title: | Virology |
| Volume: | 575 |
| Start Page: | 10 |
| End Page: | 19 |
| Publisher DOI: | 10.1016/j.virol.2022.08.003 |
| Abstract: | Nelson Bay orthoreovirus (NBV) is an emerging bat-borne virus and causes respiratory tract infections in humans sporadically. Over the last two decades, several strains genetically related to NBV were isolated from humans and various bat species, predominantly in Southeast Asia (SEA), suggesting a high prevalence of the NBV species in this region. In this study, an orthoreovirus (ORV) belonging to the NBV species was isolated from Indonesian fruit bats' feces, tentatively named Paguyaman orthoreovirus (PgORV). Serological studies revealed that 81.2% (108/ 133) of Indonesian fruit bats sera had neutralizing antibodies against PgORV. Whole-genome sequencing and phylogenetic analysis of PgORV suggested the occurrence of past reassortments with other NBV strains isolated in SEA, indicating the dispersal and circulation of NBV species among bats in this region. Intranasal PgORV inoculation of laboratory mice caused severe pneumonia. Our study characterized PgORV's unique genetic background and highlighted the potential risk of PgORV-related diseases in Indonesia. |
| Rights: | © 2002. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90622 |
| Appears in Collections: | 人獣共通感染症国際共同研究所 (International Institute for Zoonosis Control) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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