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Application of a simple DNA damage model developed for electrons to proton irradiation

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Title: Application of a simple DNA damage model developed for electrons to proton irradiation
Authors: Matsuya, Yusuke Browse this author →KAKEN DB
Kai, Takeshi Browse this author →KAKEN DB
Parisi, Alessio Browse this author
Yoshii, Yuji Browse this author
Sato, Tatsuhiko Browse this author →KAKEN DB
Keywords: proton beams
DNA damage yields
Monte Carlo track-structure simulation
Issue Date: 31-Oct-2022
Publisher: IOP Publishing
Journal Title: Physics in medicine and biology
Volume: 67
Issue: 21
Start Page: 215017
Publisher DOI: 10.1088/1361-6560/ac9a20
PMID: 36228611
Abstract: Proton beam therapy allows irradiating tumor volumes with reduced side effects on normal tissues with respect to conventional x-ray radiotherapy. Biological effects such as cell killing after proton beam irradiations depend on the proton kinetic energy, which is intrinsically related to early DNA damage induction. As such, DNA damage estimation based on Monte Carlo simulations is a research topic of worldwide interest. Such simulation is a mean of investigating the mechanisms of DNA strand break formations. However, past modellings considering chemical processes and DNA structures require long calculation times. Particle and heavy ion transport system (PHITS) is one of the general-purpose Monte Carlo codes that can simulate track structure of protons, meanwhile cannot handle radical dynamics simulation in liquid water. It also includes a simple model enabling the efficient estimation of DNA damage yields only from the spatial distribution of ionizations and excitations without DNA geometry, which was originally developed for electron track-structure simulations. In this study, we investigated the potential application of the model to protons without any modification. The yields of single-strand breaks, double-strand breaks (DSBs) and the complex DSBs were assessed as functions of the proton kinetic energy. The PHITS-based estimation showed that the DSB yields increased as the linear energy transfer (LET) increased, and reproduced the experimental and simulated yields of various DNA damage types induced by protons with LET up to about 30 keV mu m(-1). These results suggest that the current DNA damage model implemented in PHITS is sufficient for estimating DNA lesion yields induced after protons irradiation except at very low energies (below 1 MeV). This model contributes to evaluating early biological impacts in radiation therapy.
Rights: This is the Accepted Manuscript version of an article accepted for publication in Physics in Medicine & Biology. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at
Type: article (author version)
Appears in Collections:保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松谷 悠佑

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