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Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP : a nested case-control study
| Title: | Disease activity as a risk factor for venous thromboembolism in rheumatoid arthritis analysed using time-averaged DAS28CRP : a nested case-control study |
| Authors: | Yoshimura, Masaru Browse this author | | Fujieda, Yuichiro Browse this author →KAKEN DB | | Sugawara, Masanari Browse this author | | Kono, Michihito Browse this author →KAKEN DB | | Kato, Masaru Browse this author →KAKEN DB | | Yokota, Isao Browse this author →KAKEN DB | | Amengual, Olga Browse this author →KAKEN DB | | Ito, Yoichi M. Browse this author →KAKEN DB | | Atsumi, Tatsuya Browse this author →KAKEN DB |
| Keywords: | Rheumatoid arthritis | | Venous thromboembolism | | Disease activity | | Time-averaged DAS28CRP |
| Issue Date: | 1-Nov-2022 |
| Publisher: | Springer |
| Journal Title: | Rheumatology international |
| Volume: | 42 |
| Issue: | 11 |
| Start Page: | 1939 |
| End Page: | 1946 |
| Publisher DOI: | 10.1007/s00296-022-05121-4 |
| Abstract: | The objective of this study is to clarify the clinical features and risk factors of venous thromboembolism (VTE) in patients with rheumatoid arthritis (RA). We retrospectively reviewed the prevalence of VTE in RA patients who visited Hokkaido University Hospital from 2010 to 2019 and had more than 2 years of follow-up. To explore the risk to develop VTE, we selected 260 RA patients without VTE (non-VTE) via density sampling and identified the risk factors for VTE by multivariate logistic regression analysis. Univariate conditional logistic regression analysis showed older age (p < 0.0001, Odds Ratio [OR] 1.08, 95% Confidence Interval [CI] 1.04-1.14), increase of the body mass index (BMI) (p = 0.001, OR 1.17, 95% CI 1.06-1.31), higher prevalence of RA-associated lung disease (p = 0.002, OR 2.10, 95% CI 1.33-3.30) and more frequent glucocorticoid usage (p = 0.001, OR 2.09, 95% CI 1.34-3.51) in RA patients was associated with the development of VTE significantly. Furthermore, patients with higher time-averaged disease activity score 28 (DAS28) CRP were at elevated risk (p < 0.0001, OR 3.25, 95% CI 1.94-6.12). In conditional multivariate logistic regression analysis, time averaged DAS28CRP was significantly associated with the development of VTE (p = 0.0001, adjusted OR 3.40, 95% CI 1.77-7.85). Disease activity was identified as a major risk factor of VTE in patients with RA, suggesting that sustained clinical remission could be beneficial for decrease the risk of VTE. |
| Rights: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00296-022-05121-4 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90684 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 藤枝 雄一郎
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