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Ureteral morphology and pathology during urolithiasis in cats

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Title: Ureteral morphology and pathology during urolithiasis in cats
Authors: Ichii, Osamu Browse this author →KAKEN DB
Oyamada, Kazuhisa Browse this author
Mizukawa, Hazuki Browse this author →KAKEN DB
Yokoyama, Nozomu Browse this author
Namba, Takashi Browse this author
Otani, Yuki Browse this author
Elewa, Yaser Hosny Ali Browse this author →ORCID
Sasaki, Noboru Browse this author →KAKEN DB
Nakamura, Teppei Browse this author →KAKEN DB
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: Cat
Calcium oxalate
Issue Date: 10-Dec-2022
Publisher: Elsevier
Journal Title: Research in veterinary science
Volume: 151
Start Page: 10
End Page: 20
Publisher DOI: 10.1016/j.rvsc.2022.06.029
Abstract: Cats exhibit high susceptibility to urinary organ-related diseases. We investigated the healthy ureter morphol-ogies and compared these with ureters that were surgically resected distal to a urolithiasis obstruction in cats. Healthy ureters (total length 9.88 +/- 0.38 cm) developed adventitia composed of collagen fibers (ADCF), con-taining a longitudinal muscular layer, toward the distal segment. The healthy ureter was the smallest in the middle segment (4.71-6.90 cm from the urinary bladder) with significantly decreased luminal and submucosal areas compared to those in the proximal segment. Diseased cats exhibited a high incidence of calcium oxalate urolithiasis with renal dysfunction, regardless of age, sex, and body size. Diseased ureters showed increased perimeters, inflammation, and decreased nerves in ADCF. Collagen fibers were increased in the submucosal area, intermuscular spaces, and ADCF, particularly near the obstructed lesion. The mean resected ureter length was 5.66 +/- 0.49 cm, suggesting a high obstruction risk in the middle segment. The middle segment also increased the cross-sectional area of the ureter and ADCF, regardless of the distance from the obstructed lesion. The ureters in several cases either lacked the transitional epithelium, or exhibited transitional epithelial hyperplasia, and some of these formed the mucosal folds. In conclusion, we demonstrated the following characteristics and histo-pathological features of cat ureters: decreases in the ureter size, lumen area, and submucosa area from proximal to middle segment in healthy; ADCF changes in urolithiasis, including increased connective tissues with inflammation and decreased nerves. These data are important to understand the pathogenesis of feline ureteral obstruction.
Rights: © <2022>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市居 修

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