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Carotenoderma due to lycopenemia : A case report and evaluation of lycopene deposition in the skin
| Title: | Carotenoderma due to lycopenemia : A case report and evaluation of lycopene deposition in the skin |
| Authors: | Tanaka, Arisa Browse this author | | Miyauchi, Toshinari Browse this author | | Kitamura, Shinya Browse this author | | Iwata, Hiroaki Browse this author →KAKEN DB | | Hata, Hiroo Browse this author →KAKEN DB | | Ujiie, Hideyuki Browse this author →KAKEN DB |
| Keywords: | carotenoderma | | carotenoid | | lycopene | | lycopenemia | | beta-carotene |
| Issue Date: | 1-Dec-2022 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of dermatology |
| Volume: | 49 |
| Issue: | 12 |
| Start Page: | 1320 |
| End Page: | 1324 |
| Publisher DOI: | 10.1111/1346-8138.16537 |
| Abstract: | Carotenoderma is a yellow-orange coloration of the skin caused by high levels of serum carotenoids, mostly due to the excessive intake of carotenoid-rich foods. The yellowish coloration is typically observed on the palms, soles, and nasolabial folds. Although the physical appearance is prominent, the condition itself is benign and harmless. Diagnosing carotenoderma is not difficult because of its unique manifestations, but its pathophysiology remains unclear. We report a relatively rare case of carotenoderma due to lycopenemia caused by the excessive intake of lycopene-rich vegetables and fruits. Lycopene is a carotenoid component that is distinguished by the high absorption of light around 488nm. Given these characteristics, we examined a hematoxylin-eosin-stained specimen from the patient and tape-stripped samples by fluorescent microscopy with 488 nm wavelength emission and compared them with normal skin samples. Notably, the patient's samples showed a weaker autofluorescence in the stratum corneum and sweat glands. Furthermore, we measured carotenoid concentrations in the patient's skin noninvasively with Vegecheck (R) and found a higher score than the average of 24 healthy volunteers. These results support the long-held hypothesis that carotenoids are secreted in sweat and are deposited in the stratum corneum. To the best of our knowledge, no previous reports have measured skin carotenoid levels nor detailed the pathological findings of carotenoderma patients. This case further highlights that the excessive intake of lycopene causes carotenoderma and demonstrates that carotenoid deposition is particularly pronounced in the stratum corneum of the skin. |
| Rights: | This is the peer reviewed version of the following article: Tanaka, A, Miyauchi, T, Kitamura, S, Iwata, H, Hata, H & Ujiie, H. Carotenoderma due to lycopenemia: A case report and evaluation of lycopene deposition in the skin. J Dermatol. 2022; 49: 1320– 1324, which has been published in final form at doi:10.1111/1346-8138.16537. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90947 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 氏家 英之
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