| Title: | Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia |
| Authors: | Yoshida, Shota Browse this author |
| Onozawa, Masahiro Browse this author →KAKEN DB |
| Miyashita, Naoki Browse this author |
| Kimura, Hiroyuki Browse this author |
| Takahashi, Shogo Browse this author |
| Yokoyama, Shota Browse this author |
| Matsukawa, Toshihiro Browse this author |
| Hirabayashi, Shinsuke Browse this author |
| Mori, Akio Browse this author |
| Hidaka, Daisuke Browse this author |
| Minauchi, Koichiro Browse this author |
| Shigematsu, Akio Browse this author |
| Hashiguchi, Junichi Browse this author |
| Igarashi, Tetsuyuki Browse this author |
| Kakinoki, Yasutaka Browse this author |
| Tsutsumi, Yutaka Browse this author |
| Ibata, Makoto Browse this author |
| Kobayashi, Hajime Browse this author |
| Haseyama, Yoshihito Browse this author |
| Fujimoto, Katsuya Browse this author |
| Ishihara, Toshimichi Browse this author |
| Sakai, Hajime Browse this author |
| Ota, Shuichi Browse this author |
| Kondo, Takeshi Browse this author |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Complex karyotype |
| CK-AML |
| Typical CK-AML |
| Monosomy 17 |
| Deletion of 17p |
| TP53 mutation |
| Issue Date: | 1-Apr-2023 |
| Publisher: | Springer |
| Journal Title: | International journal of hematology |
| Volume: | 117 |
| Issue: | 4 |
| Start Page: | 544 |
| End Page: | 552 |
| Publisher DOI: | 10.1007/s12185-022-03522-6 |
| Abstract: | Complex karyotype acute myeloid leukemia (CK-AML) has been classified as an adverse-risk subtype. Although a few reports have further classified CK-AML as typical (including monosomy of chromosomes 5, 7 and 17 or deletion of 5q, 7q and/or 17p) or atypical, the clinical features of these subtypes in Japanese patients remain unclear. We retrospectively analyzed a total of 115 patients with CK-AML, including 77 with typical CK-AML and 38 with atypical CK-AML. Median overall survival (OS) was significantly shorter in patients with typical CK-AML than atypical CK-AML (143 days vs. 369 days, P = 0.009). Among patients with typical CK-AML, those with monosomy 17 or deletion of 17p had significantly shorter OS than patients without such abnormalities (105 days vs. 165 days, P = 0.033). TP53 mutations were more predominant in patients with typical CK-AML than in patients with atypical CK-AML (69.7% vs. 32.4%, P < 0.001). Patients with typical CK-AML had a poor prognosis regardless of TP53 mutation status. Among patients with atypical CK-AML, however, prognosis was worse for those with the TP53 mutation than those without the mutation. In conclusion, prognosis is extremely poor for both typical CK-AML and atypical CK-AML with TP53 mutation. |
| Rights: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s12185-022-03522-6 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92070 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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