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Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia

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Title: Clinical features of complex karyotype in newly diagnosed acute myeloid leukemia
Authors: Yoshida, Shota Browse this author
Onozawa, Masahiro Browse this author →KAKEN DB
Miyashita, Naoki Browse this author
Kimura, Hiroyuki Browse this author
Takahashi, Shogo Browse this author
Yokoyama, Shota Browse this author
Matsukawa, Toshihiro Browse this author
Hirabayashi, Shinsuke Browse this author
Mori, Akio Browse this author
Hidaka, Daisuke Browse this author
Minauchi, Koichiro Browse this author
Shigematsu, Akio Browse this author
Hashiguchi, Junichi Browse this author
Igarashi, Tetsuyuki Browse this author
Kakinoki, Yasutaka Browse this author
Tsutsumi, Yutaka Browse this author
Ibata, Makoto Browse this author
Kobayashi, Hajime Browse this author
Haseyama, Yoshihito Browse this author
Fujimoto, Katsuya Browse this author
Ishihara, Toshimichi Browse this author
Sakai, Hajime Browse this author
Ota, Shuichi Browse this author
Kondo, Takeshi Browse this author
Teshima, Takanori Browse this author →KAKEN DB
Keywords: Complex karyotype
Typical CK-AML
Monosomy 17
Deletion of 17p
TP53 mutation
Issue Date: 1-Apr-2023
Publisher: Springer
Journal Title: International journal of hematology
Volume: 117
Issue: 4
Start Page: 544
End Page: 552
Publisher DOI: 10.1007/s12185-022-03522-6
Abstract: Complex karyotype acute myeloid leukemia (CK-AML) has been classified as an adverse-risk subtype. Although a few reports have further classified CK-AML as typical (including monosomy of chromosomes 5, 7 and 17 or deletion of 5q, 7q and/or 17p) or atypical, the clinical features of these subtypes in Japanese patients remain unclear. We retrospectively analyzed a total of 115 patients with CK-AML, including 77 with typical CK-AML and 38 with atypical CK-AML. Median overall survival (OS) was significantly shorter in patients with typical CK-AML than atypical CK-AML (143 days vs. 369 days, P = 0.009). Among patients with typical CK-AML, those with monosomy 17 or deletion of 17p had significantly shorter OS than patients without such abnormalities (105 days vs. 165 days, P = 0.033). TP53 mutations were more predominant in patients with typical CK-AML than in patients with atypical CK-AML (69.7% vs. 32.4%, P < 0.001). Patients with typical CK-AML had a poor prognosis regardless of TP53 mutation status. Among patients with atypical CK-AML, however, prognosis was worse for those with the TP53 mutation than those without the mutation. In conclusion, prognosis is extremely poor for both typical CK-AML and atypical CK-AML with TP53 mutation.
Rights: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤 真弘

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