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Solid-State Silver-Catalyzed Ring-Opening Fluorination of Cyclobutanols by Using Mechanochemistry
| Title: | Solid-State Silver-Catalyzed Ring-Opening Fluorination of Cyclobutanols by Using Mechanochemistry |
| Authors: | Isshiki, Ryota Browse this author →KAKEN DB | | Kubota, Koji Browse this author | | Ito, Hajime Browse this author →KAKEN DB |
| Keywords: | C-C bond cleavage | | fluorination | | mechanochemistry | | ball-milling | | solid-state chemistry | | silver catalysis |
| Issue Date: | 3-May-2023 |
| Publisher: | Georg Thieme Verlag |
| Journal Title: | Synlett |
| Volume: | 34 |
| Issue: | 12 |
| Start Page: | 1419 |
| End Page: | 1424 |
| Publisher DOI: | 10.1055/a-2021-9599 |
| Abstract: | In this report, we demonstrate that a ball-milling technique facilitates fast and efficient silver-catalyzed ring-opening fluorination of cyclobutanols. This is the first report of a catalytic C-C bond-cleav-age/functionalization reaction under solid-state mechanochemical con-ditions. The developed protocol affords a high yield of ?-fluorinated ke-tones within much shorter reaction times, and requires less silver catalyst and Selectfluor compared with the previous solution-based conditions. Notably, the process can be carried out in air. Because of the reduced use of chemicals and the simple time-saving experimental pro-cedures, this technique is an efficient and environmentally friendly way to access ?-fluorinated ketones. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92243 |
| Appears in Collections: | 化学反応創成研究拠点：ICReDD (Institute for Chemical Reaction Design and Discovery : ICReDD) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 一色 遼大
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