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Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina

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Title: Reduced 123I-BMIPP uptake implies decreased myocardial flow reserve in patients with chronic stable angina
Authors: Kageyama, Hiroyuki Browse this author
Morita, Koichi Browse this author
Katoh, Chietsugu Browse this author
Tsukamoto, Takahiro Browse this author
Noriyasu, Kazuyuki Browse this author
Mabuchi, Megumi Browse this author
Naya, Masanao Browse this author
Kawai, Yuko Browse this author
Tamaki, Nagara9 Browse this author →KAKEN DB
Authors(alt): 玉木, 長良9
Keywords: 123I-BMIPP
Myocardial flow reserve
Substrate shift
Long-chain fatty acid metabolism
Issue Date: 25-Jul-2005
Publisher: Springer-Verlag GmbH
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 33
Issue: 1
Start Page: 6
End Page: 12
Publisher DOI: 10.1007/s00259-005-1863-3
PMID: 16041617
Abstract: Purpose Long-chain fatty acid (LCFA) is the main energy source for normal myocardium at rest, but in ischemic myocardium, the main energy substrate shifts from LCFA to glucose. 123I-BMIPP is a radiolabeled LCFA analog. In chronic stable angina without previous infarction, we suppose that reduced 123I-BMIPP uptake is related to the substrate shift in myocardium with decreased myocardial flow reserve (MFR). The purpose of this study was to relate 123I-BMIPP uptake to rest myocardial blood flow (MBF), hyperemic MBF, and MFR assessed with 15O-water positron emission tomography (PET). Methods We enrolled 21 patients with chronic stable angina without previous infarction, all of whom underwent 123I-BMIPP single-photon emission computed tomography (SPECT) and 15O-water PET. The left ventricle was divided into 13 segments. In each segment, rest MBF and hyperemic MBF were measured by PET. 123I-BMIPP uptake was evaluated as follows: score 0=normal, 1=slightly decreased uptake, 2=moderately decreased uptake, 3=severely decreased uptake, and 4=complete defect. 123I-BMIPP uptake was compared with rest MBF, hyperemic MBF, and MFR. Results The numbers of segments with 123I-BMIPP scores 0, 1, 2, 3, and 4 were 178, 40, 25, 24, and 0, respectively. The rest MBFs for scores 0, 1, 2, and 3 were 0.93±0.25, 0.86±0.21, 0.97±0.30, and 0.99±0.37 ml/min/g, respectively. The hyperemic MBFs for scores 0, 1, 2, and 3 were 2.76±1.29, 1.84±0.74, 1.37±0.39, and 1.08±0.40 ml/min/g, respectively. The MFRs for scores 0, 1, 2, and 3 were 3.01±1.38, 2.20±0.95, 1.44±0.22, and 1.10±0.26, respectively. As 123I-BMIPP uptake declined, hyperemic MBF and MFR decreased. Conclusion In chronic stable angina without previous infarction, reduced 123I-BMIPP uptake implies decreased MFR.
Rights: The original publication is available at www.springerlink.com
Type: article (author version)
URI: http://hdl.handle.net/2115/923
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 玉木 長良

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