HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton

Files in This Item:
bjr.20220720.pdf886.95 kBPDFView/Open
bjr.20220720.suppl-01.docx368.61 kBMicrosoft Word XMLView/Open
Please use this identifier to cite or link to this item:

Title: Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton
Authors: Uchinami, Yusuke Browse this author
Katoh, Norio Browse this author →KAKEN DB
Abo, Daisuke Browse this author →KAKEN DB
Morita, Ryo Browse this author
Taguchi, Hiroshi Browse this author →KAKEN DB
Fujita, Yoshihiro Browse this author
Kanehira, Takahiro Browse this author
Suzuki, Ryusuke Browse this author →KAKEN DB
Miyamoto, Naoki Browse this author
Takao, Seishin Browse this author
Matsuura, Taeko Browse this author
Sho, Takuya Browse this author
Ogawa, Koji Browse this author
Orimo, Tatsuya Browse this author
Kakisaka, Tatsuhiko Browse this author
Kobashi, Keiji Browse this author
Aoyama, Hidefumi Browse this author →KAKEN DB
Issue Date: 1-Apr-2023
Publisher: British Institute of Radiology
Journal Title: The British Journal of Radiology
Volume: 96
Issue: 1144
Start Page: 20220720
Publisher DOI: 10.1259/bjr.20220720
Abstract: Objectives: In a previous study of hepatic toxicity, the following three factors were identified to predict the benefits of proton beam therapy (PBT) for hepatocellular carcinomas (HCCs) with a maximum diameter of ≤5 cm and Child-pugh grade A (CP-A): number of tumors (1 vs ≥2), the location of tumors (hepatic hilum or others), and the sum of the diameters of lesions. The aim of this study is to analyze the association between these three factors and hepatic toxicity. Methods: We retrospectively reviewed patients of CP-A treated with PBT or photon stereotactic body radiotherapy (X-ray radiotherapy, XRT) for HCC ≤5 cm. For normal liver dose, the V5, V10, V20 (volumes receiving 5, 10, and 20 Gy at least), and the mean dose was evaluated. The albumin-bilirubin (ALBI) and CP score changes from the baseline were evaluated at 3 and 6 months after treatment. Results: In 89 patients (XRT: 48, PBT: 41), those with two or three (2-3) predictive factors were higher normal liver doses than with zero or one (0-1) factor. In the PBT group, the ALBI score worsened more in patients with 2-3 factors than those with 0-1 factor, at 3 months (median: 0.26 vs 0.02, p = 0.032) and at 6 months (median: 0.35 vs 0.10, p = 0.009). The ALBI score change in the XRT group and CP score change in either modality were not significantly different in the number of predictive factors. Conclusion: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT. Advances in knowledge: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.
Description: A correction has been published: British Journal of Radiology, Volume 97, Issue 1155, March 2024, Page 694
Description URI:
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 打浪 雄介

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University