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Hokkaido University Collection of Scholarly and Academic Papers >
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Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio-Therapy-Related Male Infertility
| Title: | Application of a Mouse Ex Vivo Spermatogenesis Model to Elucidate the Mechanism of Radio-Therapy-Related Male Infertility |
| Other Titles: | マウス精巣器官培養法を活用した放射線不妊メカニズムの解析 |
| Authors: | Kaminaga, Kiichi1 Browse this author | | Yokoya, Akinari2 Browse this author | | Fukunaga, Hisanori3 Browse this author →KAKEN DB |
| Authors(alt): | 神長, 輝一1 | | 横谷, 明徳2 | | 福永, 久典3 |
| Keywords: | radiotherapy | | male infertility | | spermatogenesis | | organ culture | | time lapse imaging |
| Issue Date: | 15-Mar-2022 |
| Publisher: | Japan Radioisotope Association |
| Journal Title: | RADIOISOTOPES |
| Volume: | 71 |
| Issue: | 1 |
| Start Page: | 35 |
| End Page: | 40 |
| Publisher DOI: | 10.3769/radioisotopes.71.35 |
| Abstract: | Fertility preservation in radiotherapy is of significance for the quality of life among post-treatment cancer survivors. In this study, using a mouse testicular tissue culture and a common X-ray irradiator, we analyzed the recovery process of spermatogenesis in spatially fractionated radiation fields, suggesting that spermatogonial stem cell migration may be involved in the recovery process. These tissue culture approaches are expected to provide a novel insight into the mechanisms of radiotherapy-related male infertility. | | 放射線治療における妊孕性の保護は，がん患者の治療後の生活にとって，重要な意義をもつ。本研究では，マウス精巣器官培養法と一般的なX線照射装置を組み合わせて，空間的に不均一な放射線場における精子形成能の損傷と回復の過程を解析したところ，生殖幹細胞の移動が回復過程に関与している可能性が示唆された。今後，このような組織培養アプローチを用いた放射線不妊メカニズム研究の発展と普及が期待される。 |
| Type: | article |
| URI: | http://hdl.handle.net/2115/92427 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 福永 久典
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