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Model development for estimating effects of boron neutron capture therapy
| Title: | Model development for estimating effects of boron neutron capture therapy |
| Other Titles: | ホウ素中性子捕捉療法の治療効果予測モデルの開発 |
| Authors: | Fukunaga, Hisanori1 Browse this author →KAKEN DB | | Matsuya, Yusuke2 Browse this author →KAKEN DB |
| Authors(alt): | 福永, 久典1 | | 松谷, 悠佑2 |
| Issue Date: | Jun-2021 |
| Publisher: | 放射線生物研究会 |
| Journal Title: | Radiation biology research communications |
| Journal Title(alt): | 放射線生物研究 |
| Volume: | 56 |
| Start Page: | 208 |
| End Page: | 223 |
| Abstract: | Boron neutron capture therapy (BNCT) is a radiation therapy that enables selective eradication of tumors by short-range α-particles and Li ions generated through the nuclear reaction between thermal neutron and 10B within tumor cells. With the development of the accelerator-based neutron source in recent decades, it is expected that BNCT will be available in many medical facilities worldwide in the future. BNCT irradiation requires a relatively long dose-delivery time after applying boron drugs to tumor cells via intravenous injection. During this period, it is suspected that the boron drug is heterogeneously accepted by cells and its concentration changes continuously, leading to the modification of curative effects from pharmacological and biological viewpoints. However, the model development for precisely predicting curative effects after BNCT irradiation is still ongoing. Here, we introduce the forefront of model development for accurately estimating effects during BNCT irradiation. | | ホウ素中性子捕捉療法(Boron Neutron Capture Therapy、BNCT)は、「腫瘍細胞選択的にホウ素薬剤を集積させ、10Bと熱中性子の核反応から生成される短飛程のα線やLiイオンを利用して、腫瘍細胞に効率的に線量を集中させる」という放射線治療であり、近年開発された加速器型中性子線源の登場により、将来、数多くの医療施設に普及すると期待される。加速器型BNCTでは、静脈注射によってホウ素薬剤を腫瘍部に取り込ませた後、比較的長い時間をかけて中性子線照射を行うため、照射中の腫瘍部ホウ素濃度分布が時空間的に不均一に変化する。したがって、核反応という物理学的な特性と、ホウ素薬剤の取り込みに係る薬理学・生物学的な特性が加速器型BNCTの治療効果に影響すると考えられるが、現在、このような特徴を考慮した数理モデルは開発途上にある。本稿では加速器型BNCT治療効果予測モデルの開発経緯と将来展望について概説する。 |
| Rights: | この論文は放射線生物研究会の許諾を得て掲載しています |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92458 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 福永 久典
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