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Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity
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| Title: | Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity |
| Authors: | Maeda, Yukari Browse this author →KAKEN DB | | Hirata, Eri Browse this author →KAKEN DB | | Takano, Yuta Browse this author | | Sakaguchi, Norihito Browse this author →KAKEN DB | | Ushijima, Natsumi Browse this author →KAKEN DB | | Saeki, Ayumi Browse this author →KAKEN DB | | Kimura, Sadahito Browse this author →KAKEN DB | | Shibata, Ken-ichiro Browse this author →KAKEN DB | | Yudasaka, Masako Browse this author →KAKEN DB | | Yokoyama, Atsuro Browse this author →KAKEN DB |
| Issue Date: | 30-Sep-2020 |
| Publisher: | Elsevier |
| Journal Title: | Carbon |
| Volume: | 166 |
| Start Page: | 36 |
| End Page: | 45 |
| Publisher DOI: | 10.1016/j.carbon.2020.04.040 |
| Abstract: | This work demonstrates that certain medically-approved drugs possess dual functions such that they exhibit intrinsic drug effects and can assist in dispersing carbon nanomaterials. Two types of carbon nanohorns (CNHs) (unoxidized: as-CNH, oxidized: CNHox550) and carbon nanotubes (CNTs) were successfully dispersed in aqueous solutions using minocycline (MC) as a dispersant. Absorption spectra, thermogravimetric analyses and theoretical calculations demonstrated that the MC was attached to the CNHs in these dispersions. The antibacterial activities of these MC/CNH complexes were examined using Streptcoccus mutans and Aggregatibacter actinomycetemcomitans, and the MC/as-CNH complex was found to maintain the same bacterial growth inhibition activity as the original MC. Electron microscopy observations suggested direct contact of the MC/CNH complexes with the bacteria, presumably allowing delivery of the MC. The results obtained from our study demonstrate that drug/nanocarbon complexes have potential applications in drug delivery. |
| Rights: | ©2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92848 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 前田 由佳利
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