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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Health Sciences / Faculty of Health Sciences >
Peer-reviewed Journal Articles, etc >
Exposure Trends to the Non-phthalate Plasticizers DEHTP, DINCH, and DEHA in Children from 2012 to 2017 : The Hokkaido Study
| Title: | Exposure Trends to the Non-phthalate Plasticizers DEHTP, DINCH, and DEHA in Children from 2012 to 2017 : The Hokkaido Study |
| Authors: | Ketema, Rahel Mesfin Browse this author →KAKEN DB | | Kasper-Sonnenberg, Monika Browse this author | | Ait Bamai, Yu Browse this author →KAKEN DB | | Miyashita, Chihiro Browse this author →KAKEN DB | | Koch, Holger M. Browse this author | | Paelmke, Claudia Browse this author | | Kishi, Reiko Browse this author →KAKEN DB | | Ikeda, Atsuko Browse this author →KAKEN DB |
| Keywords: | DEHTP | | DINCH | | DEHA | | human biomonitoring | | urine | | children | | daily intake |
| Issue Date: | 28-Jul-2023 |
| Publisher: | American Chemical Society |
| Journal Title: | Environmental science & technology |
| Volume: | 57 |
| Issue: | 32 |
| Start Page: | 11926 |
| End Page: | 11936 |
| Publisher DOI: | 10.1021/acs.est.3c03172 |
| PMID: | 37506071 |
| Abstract: | Phthalates owing to their endocrine-disrupting effects are regulated in certain products, leading to their replacement with substitutions such as di-2-ethylhexyl terephthalate (DEHTP), 1,2-cyclohexane dicarboxylic acid di(isononyl) ester (DINCH), and di(2-ethylhexyl) adipate (DEHA). However, information on human exposure to these substitutes, especially in susceptible subpopulations such as children, is limited. Thus, we examined the levels and exposure trends of DEHTP, DINCH, and DEHA metabolites in 7 year-old Japanese school children. In total, 180 urine samples collected from 2012 to 2017 were used to quantify 10 DEHTP, DINCH, and DEHA metabolites via isotope dilution liquid chromatography with tandem mass spectrometry. DEHTP and DINCH metabolites were detected in 95.6 and 92.2% of the children, respectively, and DEHA was not detected. This study, annually conducted between 2012 and 2017, revealed a significant (p < 0.05) 5-fold increase in DEHTP metabolites and a 2-fold increase in DINCH metabolites. However, the maximum estimated internal exposures were still below the health-based guidance and toxicological reference values. Exposure levels to DEHTP and DINCH have increased considerably in Japanese school children. DEHA is less relevant. Future studies are warranted to closely monitor the increasing trend in different aged and larger populations and identify the potential health effects and sources contributing to increasing exposure and intervene if necessary. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science & Technology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-TXRRPQFWQZXXPFP2AX65. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92850 |
| Appears in Collections: | 保健科学院・保健科学研究院 (Graduate School of Health Sciences / Faculty of Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 荒木（池田） 敦子
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