| Title: | Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma |
| Authors: | Sekiya, Sho Browse this author |
| Fukuda, Junki Browse this author |
| Yamamura, Ryodai Browse this author →KAKEN DB |
| Ooshio, Takako Browse this author →KAKEN DB |
| Satoh, Yusuke Browse this author |
| Kosuge, Shinya Browse this author |
| Sato, Reo Browse this author |
| Hatanaka, Kanako C. Browse this author |
| Hatanaka, Yutaka Browse this author →KAKEN DB |
| Mitsuhashi, Tomoko Browse this author →KAKEN DB |
| Nakamura, Toru Browse this author →KAKEN DB |
| Matsuno, Yoshihiro Browse this author →KAKEN DB |
| Hirano, Satoshi Browse this author →KAKEN DB |
| Sonoshita, Masahiro Browse this author →KAKEN DB |
| Issue Date: | 15-Aug-2023 |
| Publisher: | American Association for Cancer Research (AACR) |
| Journal Title: | Cancer research |
| Volume: | 83 |
| Issue: | 16 |
| Start Page: | 2704 |
| End Page: | 2715 |
| Publisher DOI: | 10.1158/0008-5472.CAN-22-3762 |
| Abstract: | Significant progress has been made in understanding the pathogenesis of pancreatic ductal adenocarcinoma (PDAC) by generating and using murine models. To accelerate drug discovery by identifying novel therapeutic targets on a systemic level, here we generated a Drosophila model mimicking the alterations), which is associated with the worst prognosis in patients. The '4-hit' flies displayed epithelial transformation and decreased survival. Comprehensive genetic screening of their entire kinome revealed kinases including MEK and AURKB as therapeutic targets. Consistently, a combination of the MEK |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92957 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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