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Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains

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Title: Spatial diversity in gene expression for VDCCγ subunit family in developing and adult mouse brains
Authors: Fukaya, Masahiro1 Browse this author
Yamazaki, Maya Browse this author
Sakimura, Kenji Browse this author
Watanabe, Masahiko Browse this author →KAKEN DB
Authors(alt): 深谷, 昌弘1
Keywords: VDCCγ subunit
In situ hybridization
Issue Date: 19-Sep-2005
Publisher: Elsevier Ireland Ltd and the Japan Neuroscience Society
Journal Title: Neuroscience Research
Volume: 53
Issue: 4
Start Page: 376
End Page: 383
Publisher DOI: 10.1016/j.neures.2005.08.009
PMID: 16171881
Abstract: The γ subunit of voltage-dependent Ca2+ channels (VDCCs) is characterized by molecular diversity and regulation of AMPA-type glutamate receptors as well as VDCCs. In the present study, we examined expressions for the VDCCγ1–8 subunit mRNAs in developing and adult mouse brains by in situ hybridization. In adult brains, the γ2 and γ7 subunit mRNAs were widely expressed in various grey matter regions with the highest level in cerebellar Purkinje cells and granule cells. The γ3 and γ8 subunit mRNAs predominated in the telencephalon, with the latter being at striking levels in the hippocampus. The γ4 subunit mRNA was enriched in the olfactory bulb, striatum, thalamus and hypothalamus. The γ5 subunit mRNA was abundant in the olfactory bulb, hippocampal CA2, thalamus, inferior colliculus and Bergmann glia. Transcripts of these subunits were detected in embryonic brains: some showed well-preserved spatial patterns (γ2, γ5, γ7 and γ8), while others underwent developmental up- (γ3) or down-regulation (γ4). In contrast, the γ1 and γ6 subunit mRNAs were negative or very low throughout brain development. Therefore, the present study has revealed spatial diversity in gene expression for individual VDCCγ subunits, presumably reflecting functional diversity of this protein family and their differential involvement in neural function.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 深谷 昌弘

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