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Molecular regulation of gonadotropin secretion by gonadotropin-releasing hormone in salmonid fishes

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Title: Molecular regulation of gonadotropin secretion by gonadotropin-releasing hormone in salmonid fishes
Authors: Ando, Hironori Browse this author
Urano, Akihisa Browse this author
Keywords: GnRH
GnRH receptor
GTH
gene expression
signal transduction pathway
salmon
seasonal reproduction
spawning migration
Issue Date: Apr-2005
Publisher: Zoological Society of Japan
Journal Title: Zoological Science
Volume: 22
Issue: 4
Start Page: 379
End Page: 389
Publisher DOI: 10.2108/zsj.22.379
Abstract: Gonadotropin-releasing hormone (GnRH) plays a central role in the control of reproductive function in vertebrates. In salmonids, salmon GnRH (sGnRH) secreted by preoptic GnRH neurons regulates gonadal maturation through stimulation of synthesis and release of pituitary gonadotropins (GTHs). In addition, several lines of our evidence indicate that sGnRH is involved in spawning behavior, and serves to integrate the gonadal maturation with the reproductive behavior. A growing number of studies show that the effects of GnRH are mediated by multiple subtypes of GnRH receptors, successive multiple signaling pathways, and finally multiple transcription factors which act cooperatively to stimulate transcription of GTH subunit genes. This complex regulatory system of the action of GnRH may serve as a molecular basis of divergent physiological strategies of reproductive success in various vertebrate species. In this article, recent data on the molecular mechanisms of action of GnRH are reviewed with special reference to the regulation of synthesis and release of GTHs in the pituitary of salmonids to elucidate the multifunctional action of GnRH.
Type: article (author version)
URI: http://hdl.handle.net/2115/13707
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浦野 明央

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