HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Faculty of Pharmaceutical Sciences >
Peer-reviewed Journal Articles, etc >

Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA

Files in This Item:
FL580-1.pdf8.33 MBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/1391

Title: Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA
Authors: Muromoto, Ryuta Browse this author
Okabe, Kanako Browse this author
Fujimuro, Masahiro Browse this author
Sugiyama, Kenji Browse this author
Yokosawa, Hideyoshi Browse this author
Seya, Tsukasa Browse this author
Matsuda, Tadashi7 Browse this author →KAKEN DB
Authors(alt): 松田, 正7
Keywords: Signal transducer and activator of transcription 3
Kaposi’s sarcoma-associated herpesvirus
latency-associated nuclear antigen
PEL, primary effusion lymphoma
Issue Date: 2005
Publisher: Federation of European Biochemical Societies Published by Elsevier B.V.
Journal Title: Febs Letters
Volume: 580
Issue: 1
Start Page: 93
End Page: 98
Publisher DOI: 10.1016/j.febslet.2005.11.057
PMID: 16364321
Abstract: The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) is known to modulate viral and cellular gene expression. We show that LANA directly associates with an IL-6 signal transducer, STAT3 and that LANA enhances the transcriptional activity of STAT3. Coimmunoprecipitation studies documented a physical interaction between LANA and STAT3 in transiently transfected 293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line. Furthermore, small-interfering RNA-mediated reduction of LANA expression decreased the STAT3-dependent transcription in KSHV-positive PEL cells, whereas overexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphoma cells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, and may have implications for the pathogenesis of KSHV-associated diseases.
Relation: http://www.sciencedirect.com/science/journal/00145793
Type: article (author version)
URI: http://hdl.handle.net/2115/1391
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

 - Hokkaido University