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Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA
| Title: | Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA |
| Authors: | Muromoto, Ryuta Browse this author | | Okabe, Kanako Browse this author | | Fujimuro, Masahiro Browse this author | | Sugiyama, Kenji Browse this author | | Yokosawa, Hideyoshi Browse this author | | Seya, Tsukasa Browse this author | | Matsuda, Tadashi7 Browse this author →KAKEN DB |
| Authors(alt): | 松田, 正7 |
| Keywords: | Signal transducer and activator of transcription 3 | | Kaposi’s sarcoma-associated herpesvirus | | latency-associated nuclear antigen | | PEL, primary effusion lymphoma |
| Issue Date: | 2005 |
| Publisher: | Federation of European Biochemical Societies Published by Elsevier B.V. |
| Journal Title: | Febs Letters |
| Volume: | 580 |
| Issue: | 1 |
| Start Page: | 93 |
| End Page: | 98 |
| Publisher DOI: | 10.1016/j.febslet.2005.11.057 |
| PMID: | 16364321 |
| Abstract: | The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) is known to modulate viral and cellular gene expression. We show that LANA directly associates with an IL-6 signal transducer, STAT3 and that LANA enhances the transcriptional activity of STAT3. Coimmunoprecipitation studies documented a physical interaction between LANA and STAT3 in transiently transfected 293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line. Furthermore, small-interfering RNA-mediated reduction of LANA expression decreased the STAT3-dependent transcription in KSHV-positive PEL cells, whereas overexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphoma cells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, and may have implications for the pathogenesis of KSHV-associated diseases. |
| Relation: | http://www.sciencedirect.com/science/journal/00145793 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/1391 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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