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Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA
Title: | Physical and functional interactions between STAT3 and Kaposi's Sarcoma-associated Herpesvirus-encoded LANA |
Authors: | Muromoto, Ryuta Browse this author | Okabe, Kanako Browse this author | Fujimuro, Masahiro Browse this author | Sugiyama, Kenji Browse this author | Yokosawa, Hideyoshi Browse this author | Seya, Tsukasa Browse this author | Matsuda, Tadashi7 Browse this author →KAKEN DB |
Authors(alt): | 松田, 正7 |
Keywords: | Signal transducer and activator of transcription 3 | Kaposi’s sarcoma-associated herpesvirus | latency-associated nuclear antigen | PEL, primary effusion lymphoma |
Issue Date: | 2005 |
Publisher: | Federation of European Biochemical Societies Published by Elsevier B.V. |
Journal Title: | Febs Letters |
Volume: | 580 |
Issue: | 1 |
Start Page: | 93 |
End Page: | 98 |
Publisher DOI: | 10.1016/j.febslet.2005.11.057 |
PMID: | 16364321 |
Abstract: | The Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded latency-associated nuclear antigen (LANA) is known to modulate viral and cellular gene expression. We show that LANA directly associates with an IL-6 signal transducer, STAT3 and that LANA enhances the transcriptional activity of STAT3. Coimmunoprecipitation studies documented a physical interaction between LANA and STAT3 in transiently transfected 293T cells as well as the KSHV-infected primary effusion lymphoma (PEL) cell line. Furthermore, small-interfering RNA-mediated reduction of LANA expression decreased the STAT3-dependent transcription in KSHV-positive PEL cells, whereas overexpression of LANA enhanced STAT3 activity in KSHV-negative B lymphoma cells. These data demonstrate that LANA is a transcriptional co-activator of STAT3, and may have implications for the pathogenesis of KSHV-associated diseases. |
Relation: | http://www.sciencedirect.com/science/journal/00145793 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/1391 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 正
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