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Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling

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タイトル: Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling
著者: Fukunaka, Tadashi 著作を一覧する
Golman, Boris 著作を一覧する
Shinohara, Kunio 著作を一覧する
キーワード: Fluidized-bed jet-mill
Kinetics
Batch grinding
Mathematical model
Ethenzamide
発行日: 2006年 3月27日
出版者: ELSEVIER SCIENCE BV
誌名: International Journal of Pharmaceutics
巻: 311
号: 1-2
開始ページ: 89
終了ページ: 96
出版社 DOI: 10.1016/j.ijpharm.2005.12.018
抄録: Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a mathematical model using only the first Kapur function, and it was consistent with experimental data satisfactorily. As the shape of the function was much different from that of inorganic compound and peculiar to API, a cubic function with respect to particle diameter was defined newly and well fitted to the experimental data. The function was also found to be affected by the operating parameters as the grinding gas pressure, the charge weight of raw material and the linear velocity at the grinding nozzle. According to the assessments of the breakage and the selection functions derived from the first Kapur function, it was found that the grinding mechanism of Ethenzamide particles was related with particle attrition mainly.
Relation (URI): http://www.sciencedirect.com/science/journal/03785173
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/14417
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 篠原 邦夫

 

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