|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Engineering / Faculty of Engineering >
Peer-reviewed Journal Articles, etc >
Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling
| Title: | Batch grinding kinetics of Ethenzamide particles by fluidized-bed jet-milling |
| Authors: | Fukunaka, Tadashi1 Browse this author | | Golman, Boris Browse this author | | Shinohara, Kunio3 Browse this author |
| Authors(alt): | 福中, 唯史1 | | 篠原, 邦夫3 |
| Keywords: | Fluidized-bed jet-mill | | Kinetics | | Batch grinding | | Mathematical model | | Ethenzamide |
| Issue Date: | 27-Mar-2006 |
| Publisher: | ELSEVIER SCIENCE BV |
| Journal Title: | International Journal of Pharmaceutics |
| Volume: | 311 |
| Issue: | 1-2 |
| Start Page: | 89 |
| End Page: | 96 |
| Publisher DOI: | 10.1016/j.ijpharm.2005.12.018 |
| Abstract: | Ethenzamide solids as a representative active pharmaceutical ingredient (API) were batch-ground by means of a fluidized-bed jet-mill which is a relatively new equipment and promising for production in the pharmaceutical field. Thus, the characteristic grinding mechanism was investigated. As a result, the variation of the residual ratio with grinding time after milling was expressed simply by a mathematical model using only the first Kapur function, and it was consistent with experimental data satisfactorily. As the shape of the function was much different from that of inorganic compound and peculiar to API, a cubic function with respect to particle diameter was defined newly and well fitted to the experimental data. The function was also found to be affected by the operating parameters as the grinding gas pressure, the charge weight of raw material and the linear velocity at the grinding nozzle. According to the assessments of the breakage and the selection functions derived from the first Kapur function, it was found that the grinding mechanism of Ethenzamide particles was related with particle attrition mainly. |
| Relation: | http://www.sciencedirect.com/science/journal/03785173 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/14417 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 篠原 邦夫
|
