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Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14509

Title: Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins
Authors: Ohno, Yusuke Browse this author
Kihara, Akio Browse this author →KAKEN DB
Sano, Takamitsu Browse this author →KAKEN DB
Igarashi, Yasuyuki Browse this author →KAKEN DB
Keywords: DHHC cysteine-rich domain
Palmitoylation
Protein acyltransferase
Issue Date: Apr-2006
Publisher: Elsevier
Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Volume: 1761
Issue: 4
Start Page: 474
End Page: 483
Publisher DOI: 10.1016/j.bbalip.2006.03.010
PMID: 16647879
Abstract: Increasing evidence indicates that DHHC cysteine-rich domain-containing proteins (DHHC proteins) are protein acyltransferases. Although multiple DHHC proteins are found in eukaryotes, characterization has been examined for only a few. Here, we have cloned all the yeast and human DHHC genes and investigated their intracellular localization and tissue-specific expression. Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole. Human DHHC mRNAs also differ in their tissue-specific expression. These results may provide clues to aid in discovering the specific function(s) of each DHHC protein.
Relation: http://www.sciencedirect.com/science/journal/13881981
Type: article (author version)
URI: http://hdl.handle.net/2115/14509
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 木原 章雄

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