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MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains.

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タイトル: MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains.
著者: Fujimura, Yuiko 著作を一覧する
Iwashita, Misato 著作を一覧する
Matsuzaki, Fumio 著作を一覧する
Yamamoto, Tohru 著作を一覧する
キーワード: Spinal neuron
IgSF
MAM domain
Muscle
発行日: 2006年 7月26日
出版者: Elsevier B.V.
誌名: Brain Research
巻: 1101
号: 1
開始ページ: 12
終了ページ: 19
出版社 DOI: 10.1016/j.brainres.2006.05.030
抄録: Molecules belonging to the immunoglobulin superfamily (IgSF) are reported to be involved in intercellular communication in the developing nervous system. We have identified a novel GPI-anchored IgSF molecule containing a MAM (meprin, A5 protein, PTPμ) domain, named MDGA1, by screening for genes that are expressed by subpopulations of cells in the embryonic chick spinal cord. MDGA1 is selectively expressed by brachial LMCm motor neurons, some populations of DRG neurons, and interneurons. We found that MDGA1 interacts heterophilically with axon-rich regions, mainly through its MAM domain. Interestingly, MDGA1 also interacts with differentiating muscle through its N-terminal region, which contains Ig domains. These results suggest that MDGA1 functions in MDGA1-expressing nerves en route to and at their target site.
Relation (URI): http://www.sciencedirect.com/science/journal/00068993
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/14615
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 山本 融

 

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