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An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc

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タイトル: An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc
著者: Kubo, Naoki 著作を一覧する
Zhao, Songji 著作を一覧する
Kinda, Akiyoshi 著作を一覧する
Motomura, Nobutoku 著作を一覧する
Katoh, Chietsugu 著作を一覧する
Kuge, Yuji 著作を一覧する
Tamaki, Nagara 著作を一覧する
キーワード: Single photon emission computed tomography
Pinhole collimator
Small animal imaging
Fluorine-18 deoxyglucose
Dual-isotope imaging
発行日: 2004年 3月
出版者: Elsevier B.V.
誌名: International Congress Series
巻: 1264
開始ページ: 275
終了ページ: 279
出版社 DOI: 10.1016/j.ics.2004.01.003
抄録: We have developed a pinhole collimator for small animal imaging using dual-isotopes, such as gamma and positron emitters. A lead cylinder containing a pinhole was placed around the subject (a small animal). The cylinder was equipped with a non-collimator gamma camera, and dual-isotope (99mTc-MIBI and 18F-FDG) SPECT was performed on a Wistar King Aptekman/hok (WKAH) rat. System planar sensitivity and Full-Width at Half-Maximum (FWHM) were measured for each radionuclide. System planar sensitivities for 99mTc and 18F SPECT were 2 and 7 cps/MBq, respectively. FWHMs for 99mTc and 18F SPECT were 2.0±0.5 and 2.7±0.5 mm, respectively. The collimator is relatively light (23 kg), and thus SPECT projection data could be acquired by rotating the gamma camera while the object remained stationary. The pinhole collimator can be used with a conventional rotating gamma camera. The present study demonstrated that it is possible to image organs in vivo in sufficient detail using the newly developed pinhole collimator. Further refinements to the experimental procedure may provide simultaneous high-resolution imaging of small animals using positron and gamma emitters with this collimator.
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 久保 直樹


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