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An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc

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Title: An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc
Authors: Kubo, Naoki Browse this author →KAKEN DB
Zhao, Songji Browse this author
Kinda, Akiyoshi Browse this author
Motomura, Nobutoku Browse this author
Katoh, Chietsugu Browse this author
Kuge, Yuji Browse this author
Tamaki, Nagara Browse this author
Keywords: Single photon emission computed tomography
Pinhole collimator
Small animal imaging
Fluorine-18 deoxyglucose
Dual-isotope imaging
Issue Date: Mar-2004
Publisher: Elsevier B.V.
Journal Title: International Congress Series
Volume: 1264
Start Page: 275
End Page: 279
Publisher DOI: 10.1016/j.ics.2004.01.003
Abstract: We have developed a pinhole collimator for small animal imaging using dual-isotopes, such as gamma and positron emitters. A lead cylinder containing a pinhole was placed around the subject (a small animal). The cylinder was equipped with a non-collimator gamma camera, and dual-isotope (99mTc-MIBI and 18F-FDG) SPECT was performed on a Wistar King Aptekman/hok (WKAH) rat. System planar sensitivity and Full-Width at Half-Maximum (FWHM) were measured for each radionuclide. System planar sensitivities for 99mTc and 18F SPECT were 2 and 7 cps/MBq, respectively. FWHMs for 99mTc and 18F SPECT were 2.0±0.5 and 2.7±0.5 mm, respectively. The collimator is relatively light (23 kg), and thus SPECT projection data could be acquired by rotating the gamma camera while the object remained stationary. The pinhole collimator can be used with a conventional rotating gamma camera. The present study demonstrated that it is possible to image organs in vivo in sufficient detail using the newly developed pinhole collimator. Further refinements to the experimental procedure may provide simultaneous high-resolution imaging of small animals using positron and gamma emitters with this collimator.
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 久保 直樹

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