Effect of chondroitin sulfate and hyaluronic acid on gene expression in a three-dimensional culture of chondrocytes


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/14716

Title:	Effect of chondroitin sulfate and hyaluronic acid on gene expression in a three-dimensional culture of chondrocytes
Authors:	Nishimoto, Shohei Browse this author
	Takagi, Mutsumi Browse this author →KAKEN DB
	Wakitani, Shigeyuki Browse this author
	Nihira, Takuya Browse this author
	Yoshida, Toshiomi Browse this author
Keywords:	chondrocyte
	chondroitin sulfate
	hyaluronic acid
	RT-PCR
Issue Date:	Jul-2005
Publisher:	The Society for Biotechnology, Japan
Journal Title:	Journal of Bioscience and Bioengineering
Volume:	100
Issue:	1
Start Page:	123
End Page:	126
Publisher DOI:	10.1263/jbb.100.123
PMID:	16233863
Abstract:	The effect of glycosaminoglycan addition on a three-dimensional (3D) culture of porcine chondrocyte cells was investigated with a view to use in cartilage regenerative medicine. Chondroitin sulfate C increased the mRNA expression of type 2 collagen, while chondroitin sulfate A did not. Hyaluronic acid of high molecular weight markedly decreased the mRNA expression of both aggrecan and type 2 collagen, although hyaluronic acid of low molecular weight showed no apparent effect.
Relation:	http://www.sbj.or.jp/
Type:	article (author version)
URI:	http://hdl.handle.net/2115/14716
Appears in Collections:	工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 高木睦

OAI-PMH ( junii2 , jpcoar_1.0 )

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