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Effects of insulin-like growth factor I on GnRH-induced gonadotropin subunit gene expressions in masu salmon pituitary cells at different stages of sexual maturation.

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Title: Effects of insulin-like growth factor I on GnRH-induced gonadotropin subunit gene expressions in masu salmon pituitary cells at different stages of sexual maturation.
Authors: Ando, Hironori Browse this author
Luo, Qiong Browse this author
Koide, Nobuhisa Browse this author
Okada, Houji Browse this author
Urano, Akihisa Browse this author
Keywords: Gonadotropin
Gonadotropin-releasing hormone
Insulin-like growth factor I
Pituitary
Gene expression
Puberty
Salmon
Issue Date: Oct-2006
Publisher: Elsevier Inc.
Journal Title: General and Comparative Endocrinology
Volume: 149
Issue: 1
Start Page: 21
End Page: 29
Publisher DOI: 10.1016/j.ygcen.2006.04.013
PMID: 16765954
Abstract: Effects of insulin-like growth factor I (IGF-I) and salmon gonadotropin-releasing hormone (sGnRH) on expression of gonadotropin (GTH) subunit genes were examined using primary pituitary cell cultures of masu salmon (Oncorhynchus masou). Fishes were assessed at three reproductive stages, i.e., in April (early maturation), in June (maturing), and in September (spawning). Amounts of GTH subunit mRNAs in pituitary cells were determined using real-time PCR after incubation with IGF-I and/or sGnRH. IGF-I alone had almost no effects on three GTH subunit mRNAs in both sexes, except for decrease in follicle-stimulating hormone (FSH) β mRNA in males in June. sGnRH alone was effective in stimulation of FSHβ and luteinizing hormone (LH) β gene expression in males in April. Thereafter it had no significant effects on GTH subunit mRNAs, although in September it tended to increase FSHβ and LHβ mRNAs in females. Co-administered IGF-I counteracted the sGnRH-induced expression of FSHβ and LHβ genes in males in April, but not in females in September. These results suggest that IGF-I is involved in direct regulation of GTH subunit genes during sexual maturation. In particular, IGF-I differently modulates sGnRH-induced GTH subunit gene expression, depending on reproductive stages.
Relation: http://www.sciencedirect.com/science/journal/00166480
Type: article (author version)
URI: http://hdl.handle.net/2115/14804
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 浦野 明央

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