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Rhythmic contraction and intracellular Ca2 +  oscillatory rhythm in spontaneously beating cultured cardiac myocytes

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タイトル: Rhythmic contraction and intracellular Ca2 +  oscillatory rhythm in spontaneously beating cultured cardiac myocytes
著者: Nakayama, Yukako 著作を一覧する
Kawahara, Koichi 著作を一覧する
Yoneyama, Mitsuru 著作を一覧する
Hachiro, Takeru 著作を一覧する
キーワード: Ca2 +  oscillation, rhythmic contraction
intercellular synchronization
E – C coupling
fluctuation
発行日: 2005年10月
出版者: Taylor & Francis
誌名: Biological Rhythm Research
巻: 36
号: 4
開始ページ: 315
終了ページ: 324
出版社 DOI: 10.1080/09291010500124597
抄録: Cultured cardiac myocytes from neonatal rats show spontaneous and rhythmic contractions. The intracellular concentration of free Ca2 +  also changes rhythmically, associated with the rhythmic contraction of myocytes (Ca2 +  oscillation). This study aims to elucidate whether spontaneous rhythmic contraction affects the dynamics of intracellular Ca2 +  oscillation in cultured cardiac myocytes. In cultures at four days in vitro (4 DIV), spontaneous Ca2 +  oscillation was synchronized among myocytes. Treatment of cultures with an uncoupler of E – C coupling resulted in a cessation of the spontaneous contraction of cardiac myocytes, but did not abolish the Ca2 +  oscillation. The intercellular synchronization of intracellular Ca2 +  oscillation persisted, and both the intervals and the fluctuation of the oscillation tended to increase after the termination of rhythmic contraction. The present study demonstrated that mechanical factors associated with rhythmic contraction did not affect the intercellular synchronization of intracellular Ca2 +  oscillation, but possibly contributed to the stability of the oscillatory rhythm.
関連URI: http://www.taylorandfrancisgroup.com/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/14899
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 河原 剛一

 

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