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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Information Science and Technology / Faculty of Information Science and Technology >
Peer-reviewed Journal Articles, etc >
Rhythmic contraction and intracellular Ca2 + oscillatory rhythm in spontaneously beating cultured cardiac myocytes
| Title: | Rhythmic contraction and intracellular Ca2 + oscillatory rhythm in spontaneously beating cultured cardiac myocytes |
| Authors: | Nakayama, Yukako Browse this author | | Kawahara, Koichi Browse this author →KAKEN DB | | Yoneyama, Mitsuru Browse this author | | Hachiro, Takeru Browse this author |
| Keywords: | Ca2 + oscillation, rhythmic contraction | | intercellular synchronization | | E – C coupling | | fluctuation |
| Issue Date: | Oct-2005 |
| Publisher: | Taylor & Francis |
| Journal Title: | Biological Rhythm Research |
| Volume: | 36 |
| Issue: | 4 |
| Start Page: | 315 |
| End Page: | 324 |
| Publisher DOI: | 10.1080/09291010500124597 |
| Abstract: | Cultured cardiac myocytes from neonatal rats show spontaneous and rhythmic contractions. The intracellular concentration of free Ca2 + also changes rhythmically, associated with the rhythmic contraction of myocytes (Ca2 + oscillation). This study aims to elucidate whether spontaneous rhythmic contraction affects the dynamics of intracellular Ca2 + oscillation in cultured cardiac myocytes. In cultures at four days in vitro (4 DIV), spontaneous Ca2 + oscillation was synchronized among myocytes. Treatment of cultures with an uncoupler of E – C coupling resulted in a cessation of the spontaneous contraction of cardiac myocytes, but did not abolish the Ca2 + oscillation. The intercellular synchronization of intracellular Ca2 + oscillation persisted, and both the intervals and the fluctuation of the oscillation tended to increase after the termination of rhythmic contraction. The present study demonstrated that mechanical factors associated with rhythmic contraction did not affect the intercellular synchronization of intracellular Ca2 + oscillation, but possibly contributed to the stability of the oscillatory rhythm. |
| Relation: | http://www.taylorandfrancisgroup.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/14899 |
| Appears in Collections: | 情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 河原 剛一
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