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Graduate School of Science / Faculty of Science >
Peer-reviewed Journal Articles, etc >
Biosynthetic Study of FR-900848: Origin of the Aminodeoxynucleoside Part
| Title: | Biosynthetic Study of FR-900848: Origin of the Aminodeoxynucleoside Part |
| Authors: | Watanabe, Hiroaki Browse this author | | Tokiwano, Tetsuo Browse this author | | Oikawa, Hideaki Browse this author |
| Keywords: | FR-900848 | | antifungal agent | | polycyclopropane | | aminodeoxynucleoside |
| Issue Date: | Sep-2006 |
| Publisher: | 日本抗生物質学術協議会 |
| Journal Title: | The Journal of Antibiotics |
| Volume: | 59 |
| Issue: | 9 |
| Start Page: | 607 |
| End Page: | 610 |
| Abstract: | Biosynthetic studies of the antifungal agent, FR-900848, were undertaken by feeding experiments with D-[U-13C6]glucose, L-[4-13C]aspartate, [5,5-2H2]dihydrouridine and [5,5-2H2]dihydrouracil. The 5´´-amino-5´´-deoxy-5´,6´-dihydrouridine moiety was derived from ribose and aspartate. Based on the feeding experiments, a detailed biosynthetic pathway producing the aminodeoxydihydrouridine moiety of FR-900848 was proposed. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/15826 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 及川 英秋
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