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Activity-dependent regulation of BRINP family genes

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タイトル: Activity-dependent regulation of BRINP family genes
著者: Motomiya, Makoto 著作を一覧する
Kobayashi, Makoto 著作を一覧する
Iwasaki, Norimasa 著作を一覧する
Minami, Akio 著作を一覧する
Matsuoka, Ichiro 著作を一覧する
キーワード: Hippocampus
BMP/RA-inducible neural-specific protein
Activity-dependent gene expression
Cell cycle
Glutamate receptor
発行日: 2007年 1月19日
出版者: Elsevier Inc.
誌名: Biochemical and Biophysical Research Communications
巻: 352
号: 3
開始ページ: 623
終了ページ: 629
出版社 DOI: 10.1016/j.bbrc.2006.11.072
抄録: We previously identified a family of novel developmentally regulated genes: BRINP1, 2, and 3, which are predominantly and widely expressed in the CNS from earlier developmental stages to adulthood. In the present study, we investigated the activity-dependent regulation of BRINP expression in the CNS. Among the three BRINP genes, BRINP1-mRNA was specifically up-regulated in the dentate gyrus of mouse hippocampus by kainic acid treatment. In cultured hippocampal neurons, the induction of BRINP1-mRNA was also observed by the activation of glutamate receptors. Although BDNF-mRNA is up-regulated in a similar activity-dependent manner, BDNF itself did not induce BRINP1-mRNA. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.
Relation (URI):
資料タイプ: article (author version)
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 松岡 一郎


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