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Activity-dependent regulation of BRINP family genes

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Title: Activity-dependent regulation of BRINP family genes
Authors: Motomiya, Makoto Browse this author
Kobayashi, Makoto Browse this author
Iwasaki, Norimasa Browse this author →KAKEN DB
Minami, Akio Browse this author →KAKEN DB
Matsuoka, Ichiro Browse this author
Keywords: Hippocampus
BMP/RA-inducible neural-specific protein
Activity-dependent gene expression
Cell cycle
Glutamate receptor
Issue Date: 19-Jan-2007
Publisher: Elsevier Inc.
Journal Title: Biochemical and Biophysical Research Communications
Volume: 352
Issue: 3
Start Page: 623
End Page: 629
Publisher DOI: 10.1016/j.bbrc.2006.11.072
PMID: 17141197
Abstract: We previously identified a family of novel developmentally regulated genes: BRINP1, 2, and 3, which are predominantly and widely expressed in the CNS from earlier developmental stages to adulthood. In the present study, we investigated the activity-dependent regulation of BRINP expression in the CNS. Among the three BRINP genes, BRINP1-mRNA was specifically up-regulated in the dentate gyrus of mouse hippocampus by kainic acid treatment. In cultured hippocampal neurons, the induction of BRINP1-mRNA was also observed by the activation of glutamate receptors. Although BDNF-mRNA is up-regulated in a similar activity-dependent manner, BDNF itself did not induce BRINP1-mRNA. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松岡 一郎

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