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Activity-dependent regulation of BRINP family genes
| Title: | Activity-dependent regulation of BRINP family genes |
| Authors: | Motomiya, Makoto Browse this author | | Kobayashi, Makoto Browse this author | | Iwasaki, Norimasa Browse this author →KAKEN DB | | Minami, Akio Browse this author →KAKEN DB | | Matsuoka, Ichiro Browse this author |
| Keywords: | Hippocampus | | BMP/RA-inducible neural-specific protein | | BRINP | | Activity-dependent gene expression | | Cell cycle | | Glutamate receptor |
| Issue Date: | 19-Jan-2007 |
| Publisher: | Elsevier Inc. |
| Journal Title: | Biochemical and Biophysical Research Communications |
| Volume: | 352 |
| Issue: | 3 |
| Start Page: | 623 |
| End Page: | 629 |
| Publisher DOI: | 10.1016/j.bbrc.2006.11.072 |
| PMID: | 17141197 |
| Abstract: | We previously identified a family of novel developmentally regulated genes: BRINP1, 2, and 3, which are predominantly and widely expressed in the CNS from earlier developmental stages to adulthood. In the present study, we investigated the activity-dependent regulation of BRINP expression in the CNS. Among the three BRINP genes, BRINP1-mRNA was specifically up-regulated in the dentate gyrus of mouse hippocampus by kainic acid treatment. In cultured hippocampal neurons, the induction of BRINP1-mRNA was also observed by the activation of glutamate receptors. Although BDNF-mRNA is up-regulated in a similar activity-dependent manner, BDNF itself did not induce BRINP1-mRNA. From these results, the physiological roles of the activity-dependent induction of BRINP1-mRNA are discussed. |
| Relation: | http://www.sciencedirect.com/science/journal/0006291X |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/17196 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松岡 一郎
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