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分子生物学的に同一クローンの再発を確認しえた biphenotypic leukemia

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Title: 分子生物学的に同一クローンの再発を確認しえた biphenotypic leukemia
Other Titles: Relapse of biphenotypic leukemia confirmed by molecular study
Authors: 小野澤, 真弘1 Browse this author
橋野, 聡2 Browse this author
泉山, 康3 Browse this author
米積, 昌克4 Browse this author
千葉, 広司5 Browse this author
近藤, 健6 Browse this author
田中, 淳司7 Browse this author
今村, 雅寛8 Browse this author
浅香, 正博9 Browse this author
Authors(alt): ONOZAWA, Masahiro1
HASHINO, Satoshi2
YONEZUMI, Masakatsu4
CHIBA, Kouji5
KONDO, Takeshi6
TANAKA, Junji7
IMAMURA, Masahiro8
ASAKA, Masahiro9
Keywords: Biphenotypic leukemia
Minimal residual disease
T-cell receptor rearrangement
Issue Date: 29-Feb-2004
Publisher: 日本臨床血液学会
Journal Title: 臨床血液
Journal Title(alt): The Japanese Journal of Clinical Hematology
Volume: 45
Issue: 2
Start Page: 161
End Page: 163
Abstract: A 60-year-old woman was admitted to our hospital to receive treatment for relapse of biphenotypic leukemia 4 years after initial presentation. Bone marrow examination revealed 53.5% lymphoblasts, which were classified as ALL-L2 with normal karyotype. Surface markers of lymphoblasts were positive for both B-cell and myeloid lineage. Immunoglobulin heavy chain and T-cell receptor gene rearrangements were investigated by PCR. Clonal rearrangement of TCRδ Vδ2-Dδ3 was detected. The same clonal rearrangement of TCRδ was found using frozen initial leukemic cells. Her leukemia was confirmed as not secondary leukemia but relapse of the initial clone. Detection of the rearrangement was also useful as a patient-specific marker for minimal residual disease.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小野澤 真弘

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