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Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/20470

Title: Genome Wide Expression Analysis of White Blood Cells and Liver of Pre-diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Using a cDNA Microarray
Authors: Iida, Shinya Browse this author
Sato, Yuichiro Browse this author
Nakaya, Akihiro Browse this author
Shinohara, Yasuo Browse this author
Hayashi, Yasuhiro Browse this author
Sawada, Akihiro Browse this author
Nagata, Hideya Browse this author
Kaji, Noritada Browse this author
Kamiya, Hiroyuki Browse this author
Baba, Yoshinobu Browse this author
Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords: white blood cell
non-insulin dependent diabetes mellitus
genetic diagnosis
cDNA microarray
Otsuka Long-Evans Tokushima fatty rat
Issue Date: Dec-2006
Publisher: Pharmaceutical Society of Japan
Journal Title: Biological & Pharmaceutical Bulletin
Volume: 29
Issue: 12
Start Page: 2451
End Page: 2459
Publisher DOI: 10.1248/bpb.29.2451
Abstract: In a prior study, we reported on a significant decrease in calpain10 gene expression in white blood cells (WBC) as well as the major insulin-target tissues including liver and adipose tissue, before the onset of diabetes in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. In this study, we extended our hypothesis that some type 2 diabetes mellitus (NIDDM) susceptible genes are up/down-regulated before the onset in WBC of OLETF rats, reflecting their up/down-regulation in major insulin-target tissues, such as the liver. We tested this hypothesis using rat cDNA microarrays. The findings show that 1080 genes are up/down-regulated by more than 2-fold compared to the controls, Long-Evans Tokushima Otsuka rats, before the onset in WBC and liver under fasted or insulin administered condition. Fifty-seven of the 1080 genes were up/down-regulated in both WBC and the liver. More than half have been reported to NIDDM susceptible genes and the remainder have not been reported to be related to NIDDM. These results indicate that there some NIDDM related genes are up/down-regulated in WBC before the onset of diabetes.
Type: article
URI: http://hdl.handle.net/2115/20470
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 紙谷 浩之

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