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Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models

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Title: Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models
Authors: Osaki, Tomohiro Browse this author
Takagi, Satoshi Browse this author →KAKEN DB
Hoshino, Yuki Browse this author →KAKEN DB
Okumura, Masahiro Browse this author →KAKEN DB
Fujinaga, Toru Browse this author
Keywords: Photodynamic therapy
Benzoporphyrin derivative monoacid ring A
Power Doppler ultrasound
Issue Date: 8-Apr-2007
Publisher: Elsevier
Journal Title: Cancer Letters
Volume: 248
Issue: 1
Start Page: 47
End Page: 57
Publisher DOI: 10.1016/j.canlet.2006.05.021
PMID: 16837129
Abstract: Photodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3 h or 15 min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval PDT enhanced the antitumor effect by damaging tumor vasculature.
Relation: http://www.sciencedirect.com/science/journal/03043835
Type: article (author version)
URI: http://hdl.handle.net/2115/22095
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大崎 智弘

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