|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models
| Title: | Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models |
| Authors: | Osaki, Tomohiro Browse this author | | Takagi, Satoshi Browse this author →KAKEN DB | | Hoshino, Yuki Browse this author →KAKEN DB | | Okumura, Masahiro Browse this author →KAKEN DB | | Fujinaga, Toru Browse this author |
| Keywords: | Photodynamic therapy | | Benzoporphyrin derivative monoacid ring A | | Power Doppler ultrasound |
| Issue Date: | 8-Apr-2007 |
| Publisher: | Elsevier |
| Journal Title: | Cancer Letters |
| Volume: | 248 |
| Issue: | 1 |
| Start Page: | 47 |
| End Page: | 57 |
| Publisher DOI: | 10.1016/j.canlet.2006.05.021 |
| PMID: | 16837129 |
| Abstract: | Photodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3 h or 15 min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval PDT enhanced the antitumor effect by damaging tumor vasculature. |
| Relation: | http://www.sciencedirect.com/science/journal/03043835 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/22095 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 大崎 智弘
|
