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Regulation of STAT3-mediated signaling by LMW-DSP2.

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Title: Regulation of STAT3-mediated signaling by LMW-DSP2.
Authors: Sekine, Y. Browse this author
Tsuji, S. Browse this author
Ikeda, O. Browse this author
Sato, N. Browse this author
Aoki, N. Browse this author
Aoyama, K. Browse this author
Sugiyama, K. Browse this author
Matsuda, T. Browse this author →KAKEN DB
Keywords: IL-6
transcriptional regulation
Issue Date: 21-Sep-2006
Publisher: Nature Publishing Group
Journal Title: Oncogene
Volume: 25
Issue: 42
Start Page: 5801
End Page: 5806
Publisher DOI: 10.1038/sj.onc.1209578
PMID: 16636663
Abstract: Signal transducer and activator of transcription 3 (STAT3), which mediates biological actions in many physiological processes, is activated by cytokines and growth factors, and has been reported to be constitutively activated in numerous cancer cells. In this study, we examined whether low molecular weight-dual specificity phosphatase two (LMW-DSP2) is involved in the regulation of the interleukin 6 (IL-6)/leukemia inhibitory factor (LIF)/STAT3-mediated signaling pathway. IL-6/LIF-induced LMW-DSP2 expression in murine testicular or hepatoma cell lines, while LMW-DSP2 overexpression in 293T cells suppressed IL-6-induced phosphorylation and activation of STAT3. Furthermore, LMW-DSP2 suppressed the expression of IL-6-induced endogenous genes. In contrast, small-interfering RNA-mediated reduction of LMW-DSP2 expression enhanced IL-6-induced STAT3-dependent transcription. In fact, LMW-DSP2 interacted with STAT3 in vivo and endogenous LMW-DSP2 bound to STAT3 in murine testicular GC-1 cells. These results strongly suggest that LMW-DSP2 acts as a negative regulator of the IL-6/LIF/STAT3-mediated signaling pathway.
Rights: Nature Publishing Group, ONCOGENE, 25, 42, 2006, 5801-5806.
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 正

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